Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases
Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases
复制标题
DOI：
10.7883/yoken1952.51.13
复制
发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Cheng, KS
中科院分区：
文献类型：
--
作者：
Lin, CW;Chang, YS;Cheng, KS
本研究旨在探讨台湾中部地区胃十二指肠疾病患者体内幽门螺杆菌的感染率及异质性。H.在74.1%（575/776）的有症状人群中检测到幽门螺杆菌感染。H.幽门螺杆菌感染率从1 - 20岁的11.1%上升到41 - 50岁的82.9%，51 - 60岁的84%。男性和女性之间的幽门螺杆菌感染率无显著差异。不同血型间H. O型血患者的幽门螺杆菌感染率（90.3%）显著高于A型血患者（41%）、B型血患者（27.4%）和AB型血患者（62%）。甲硝唑耐药率为6.7%。耐甲硝唑的H. pylori菌株女性检出率（7.69%）高于男性（6.25%），但差异无统计学意义。H. pylori菌株cagA阳性。CagA基因阳性菌株在十二指肠溃疡、十二指肠溃疡合并胃溃疡、胃溃疡和胃炎患者中的检出率分别为90.1%、90%、85.8%和69.2%，且在消化性溃疡疾病组中显著高于胃炎组。总之，甲硝唑耐药幽门螺杆菌菌株的发生率较低（6.7%），而幽门螺杆菌的患病率较高（88%）。pylori cagA阳性菌株。这项研究还证明了活性H。pylori感染与O型血阳性患者相关，cagA基因阳性与H.幽门螺杆菌菌株和消化性溃疡的发展。
This study was designed to study the in vivo prevalence and the heterogeneity of H.pylori in patients with gastroduodenal diseases in central Taiwan. H. pylori infection was detected in 74.1% (575/776) of the symptomatic population studied. The prevalence of H. pylori infection increased from 11.1% in those between the ages of one to 20, to 82.9% in those between the ages of 41 and 50, and to 84% in those between the ages of 51 and 60. There was no significant difference in the prevalence of H pylori infection between men and women. Among different blood types, the prevalence and relative risk of H. pylori infection was significantly higher in blood group O patients (90.3%) than in blood group A (41%), blood group B (27.4%), or blood group AB (62%) patients. Metronidazole resistance was found in 6.7% of the primary isolates. The prevalence of metronidazole-resistant H. pylori strains was higher in women (7.69%) than in men (6.25%), but this difference was not significant. A total of 88% of H. pylori strains were cagA-positive. CagA gene-positive strains were present in 90.1% of duodenal ulcers, 90% of duodenal ulcers combined with gastric ulcer, 85.8% of gastric ulcers, and 69.2% of gastritis patients, and was significantly higher in peptic ulcer disease groups than in the gastritis group. In conclusion, there was a low incidence (6.7%) of metronidazole-resistant H pylori strains and a high prevalence (88%) of H. pylori cagA-positive strains in central Taiwan. This study also demonstrated a significant in vivo correlation between active H. pylori infection and blood group O-positive patients, and showed a significant association between cagA gene-positive H. pylori strains and the development of peptic ulcers.