VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN - MEASUREMENTS WITH AN IMAGE ANALYZER
VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN - MEASUREMENTS WITH AN IMAGE ANALYZER
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DOI：
10.1111/j.1365-2990.1980.tb00283.x
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发表时间：
1980-01-01
影响因子：
5
通讯作者：
CORSELLIS, JAN
中科院分区：
文献类型：
--
作者：
MILLER, AKH;ALSTON, RL;CORSELLIS, JAN
对65例正常男性和65例正常女性大脑半球灰质和白色质的总体积和相对体积进行了测量。研究发现，男性的固定半球体积每十年线性下降3.5%，从20岁时的641 ml下降到100岁时的463 ml。对于女性，每十年下降1.9%，从20岁时的531 ml下降到100岁时的462 ml。在校正了注视的影响和大脑体积的长期增加后，平均半球体积在20岁至50岁之间大致保持不变（男性为558 ml，女性为474 ml）。50岁以后，男女的平均体积每十年下降约2%。灰色与白色物质的体积比在所有年龄的两性中是相同的。其平均值在20岁时为1.3，50岁时下降到1.1，然后稳步上升，到100岁时超过1.5。在实践中，不可能根据固定或长期变化的影响来校正这些测量结果。对13例老年女性痴呆患者的14侧大脑半球进行了测量。总体积比年龄匹配的正常组低18%，但灰质与白色物质的比例相同。
The total volumes and relative quantities of gray and white matter were measured in 65 normal male and 65 normal female cerebral hemispheres. Fixed hemisphere volume was found to fall linearly at 3.5% per decade for men from 641 ml at the age of 20 to 463 ml at the age of 100. For women the decrease was 1.9% per decade from 531 ml at 20 yr to 462 ml at 100 yr. After correction for the effects of fixation and for the secular increase in brain size, mean hemisphere volume remained roughly constant between the ages of 20 and 50 yr (558 ml for men, 474 ml for women). After the age of 50 the mean volume in both sexes fell at about 2% per decade. The ratio of the volumes of gray to white matter was the same for the 2 sexes at all ages. Its mean value was 1.3 at the age of 20, falling to 1.1 at the age of 50, then rising steadily to over 1.5 at 100 yr. It is impossible in practice to correct these measurements for the effects of fixation or secular change. Hemispheres (14) from 13 elderly female dements were also measured. The total volume was 18% lower than for an age-matched group of normal, but the ratio of gray to white matter was identical.