Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women
Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women
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DOI：
10.1093/ajcn/85.1.131
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发表时间：
2007-01-01
影响因子：
7.1
通讯作者：
Fairweather-Tait, Susan J.
中科院分区：
文献类型：
--
作者：
Harvey, Linda J.;Dainty, Jack R.;Fairweather-Tait, Susan J.
背景：由于胎儿发育的需要，女性在怀孕期间缺铁的风险增加。铁补充剂通常被提倡作为预防性治疗，并且通常随餐服用以减少副作用，但铁会干扰锌的吸收。目的：目的是确定从妊娠 16 周到足月期间随餐摄入铁补充剂（100 毫克铁/天，以葡萄糖酸亚铁形式）对锌状态和吸收的影响。设计：使用稳定同位素技术测量 6 名服用铁补充剂的女性和 7 名服用安慰剂的女性在怀孕早期和晚期的锌状况（可交换锌池，EZP）和锌吸收分数（FZA），这些膳食与铁补充剂或安慰剂消耗的时间不同。结果：FZA 在怀孕期间增加，与补铁无关。第 34 周的 FZA 显着高于第 16 周和第 24 周（P < 0.001），第 34 周的尿锌排泄量高于第 16 周（P = 0.02）。 EZP 的大小在整个怀孕期间保持不变，并且不受补铁的影响。补充铁剂的女性的铁含量高于安慰剂组。结论：在采用西方饮食的铁充足孕妇中，每天摄入 100 mg Fe 后，未观察到对锌代谢的不良影响。在怀孕后期观察到锌吸收效率有所提高。
Background: Women have an increased risk of iron deficiency during pregnancy because of the demands of the developing fetus. Iron supplements are commonly advocated as a prophylactic treatment and are generally taken with meals to reduce side effects, but iron can interfere with the absorption of zinc. Objective: The aim was to determine the effect of consuming an iron supplement (100 mg Fe/d as ferrous gluconate) with meals from 16 wk gestation to term on zinc status and absorption. Design: Stable-isotope techniques were used to measure zinc status (exchangeable zinc pool, EZP) and fractional zinc absorption (FZA) in early and late pregnancy from a meal consumed at a different time from that of iron supplement or placebo consumption in 6 women given iron supplements and 7 given a placebo. Results: FZA increased during pregnancy, independent of iron supplementation. FZA was significantly higher (P < 0.001) at week 34 than at weeks 16 and 24, and urinary zinc excretion was higher at week 34 than at week 16 (P = 0.02). The size of the EZP remained unchanged throughout pregnancy and was unaffected by iron supplementation. The iron status of iron-supplemented women was higher than that of the placebo group. Conclusions: In iron-replete pregnant women who consumed a Western diet, no detectable adverse effects on zinc metabolism were observed after ingestion of 100 mg Fe/d. An increase in the efficiency of zinc absorption was observed during late pregnancy.