Effect of ramelteon on middle-of-the-night balance in older adults with chronic insomnia.
Effect of ramelteon on middle-of-the-night balance in older adults with chronic insomnia.
复制标题
雷美替胺对慢性失眠老年人半夜平衡的影响。
DOI：
10.5664/jcsm.27390
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Xuejun Peng
中科院分区：
文献类型：
--
作者：
G. Zammit;S. Wang;M. Rosenthal;Xuejun Peng
研究目标
STUDY OBJECTIVES
To evaluate the effect of ramelteon on middle-of-the-night balance, mobility, and memory in older insomniacs.
METHODS
Thirty-three older adults (age > or = 65 years) with insomnia were enrolled in a single-dose, 3-way crossover study of balance after bedtime administration of ramelteon, 8 mg; zolpidem, 10 mg (positive control); or placebo. Subjects were administered study medication 30 minutes before bedtime and were awakened 2 hours after dosing to evaluate balance (Sensory Organization Test), turning speed and stability, memory (immediate and delayed word recall), and adverse events. There was a 4- to 10-day washout between treatments.
RESULTS
Ramelteon or zolpidem (positive control) was compared with placebo. There were no differences between placebo and ramelteon on the Sensory Organization Test (p = 0.837), turn time (p = 0.776), or turn sway (p = 0.982). The positive control (zolpidem) did reveal significant impairments on the Sensory Organization Test, turn time, and turn sway (p < 0.001, all). Immediate and delayed memory recall were not significantly different with ramelteon (p = 0.683 and p = 0.650, respectively). Immediate recall declined significantly with zolpidem (p = 0.002). Adverse events were infrequent (ramelteon, n = 7; placebo, n = 7; zolpidem, n = 13); none were serious.
CONCLUSION
In older adults, ramelteon did not impair middle-of-the night balance, mobility, or memory relative to placebo.
登录
查看更多内容
老年人睡眠问题的患病率和生活质量。
影响因子：
5.6
作者：
Schubert,CarlaR;Cruickshanks,KarenJ;Dalton,DaynaS;Klein,BarbaraEK;Klein,Ronald;Nondahl,DavidM
通讯作者：
Nondahl,DavidM
唑吡坦和三唑仑对人类的影响：行为和主观影响以及滥用倾向。
DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Evans,SM;Funderburk,FR;Griffiths,RR
通讯作者：
Griffiths,RR
DOI：
10.1093/gerona/55.9.m498
发表时间：
2000-09-01
影响因子：
5.1
作者：
Magaziner, J;Hawkes, W;Kenzora, J
通讯作者：
Kenzora, J
DOI：
10.1111/j.1532-5415.2005.53304.x
发表时间：
2005-06-01
影响因子：
6.3
作者：
Avidan, AY;Fries, BE;Chervin, RD
通讯作者：
Chervin, RD
影响因子：
17.7
作者：
Wang, PS;Bohn, RL;Avorn, J
通讯作者：
Avorn, J