Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson's disease
Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson's disease
复制标题
双极和单极配置组合的交错刺激治疗帕金森病双侧丘脑底刺激继发性失败
DOI：
10.1111/ncn3.12085
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发表时间：
2016
影响因子：
0.4
通讯作者：
Hattori
中科院分区：
文献类型：
--
作者：
Tsukada R;Oyama G;Shimo Y;Sekimoto S;Jo T;Nakajima A;Umemura A;Arai H;Hattori
使用交错刺激的电流控制技术在理论上可以用于最大化脑深部刺激的益处，但很少报道。1例61岁年轻型帕金森病男性患者，由于磨损和峰值剂量运动障碍，既往接受双侧丘脑底核脑深部电刺激治疗;术后3年再次出现磨损和步态障碍。通过使用单极和双极配置组合的交错刺激来调整他的深部脑刺激，因为使用单或双单极刺激增加刺激以及交错单极刺激会引起锥体副作用。在调整脑深部电刺激后，他的磨损症状和步态障碍明显改善，无任何副作用。本病例报告描述了交错刺激与单极和双极设置相结合治疗帕金森病的潜力。
Current control technology using interleaving stimulation could be theoretically useful for maximizing the benefits of deep brain stimulation, but it is seldom reported. A 61‐year‐old man with young‐onset Parkinson's disease was previously treated with bilateral subthalamic nucleus deep brain stimulation because of wearing‐off and peak‐dose dyskinesia; he again developed wearing‐off and a gait disturbance 3 years after surgery. His deep brain stimulation was adjusted by utilizing interleaving stimulation with a combination of monopolar and bipolar configurations, because increasing stimulation with single or double monopolar stimulation, and interleaving monopolar stimulation caused pyramidal side‐effects. After adjusting deep brain stimulation, his wearing‐off symptoms and gait disturbance were markedly improved without any side‐effects. The present case report describes the potential of interleaving stimulation with a combination of monopolar and bipolar settings for the treatment of Parkinson's disease.