Role of the Vnn1 pantetheinase in tissue tolerance to stress
Role of the Vnn1 pantetheinase in tissue tolerance to stress
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DOI：
10.1042/bst20140092
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发表时间：
2014-08-01
影响因子：
3.9
通讯作者：
Galland, Franck
中科院分区：
文献类型：
--
作者：
Naquet, Philippe;Pitari, Giuseppina;Galland, Franck
泛氨酸酶是辅酶A异化途径中的一种普遍存在的酶，它能将D-泛氨酸分解为半胱胺和泛酸(维生素B-5)。泛茶氨酸酶亚型由Vim(Vanin)基因编码，Vnn1是小鼠和人类的主要组织亚型。在这篇文章中，我们回顾了Vnn1在发育、修复和炎症情况下的表达调节以及Vnn1缺乏对小鼠病理模型的影响的研究结果。我们记录了Vnn1泛氨酸酶在组织需求增加的情况下的参与，并提出Vnn1通过组织中泛酸的循环和半胱胺的释放参与组织对应激的适应性反应。
Pantetheinase is an ubiquitous enzyme which hydrolyses D-pantetheine into cysteamine and pantothenate (vitamin B-5) on the dissimilative pathway of CoA. Pantetheinase isoforms are encoded by the Vim (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the present article, we review the results showing the regulation of Vnn1 expression during developmental, repair and inflammatory situations and the impact of a Vnn1 deficiency in mouse models of pathologies. We document the involvement of the Vnn1 pantetheinase in situations of increased tissue needs and propose that Vnn1 through recycling of pantothenate and release of cysteamine in tissues participates in the adaptive response of the tissue to stress.