CORONARY HEART-DISEASE MORTALITY AND ALCOHOL-CONSUMPTION IN FRAMINGHAM
CORONARY HEART-DISEASE MORTALITY AND ALCOHOL-CONSUMPTION IN FRAMINGHAM
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DOI：
10.1093/oxfordjournals.aje.a114418
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发表时间：
1986-09-01
影响因子：
5
通讯作者：
KIMBALL, AW
中科院分区：
文献类型：
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作者：
FRIEDMAN, LA;KIMBALL, AW
在最初的弗雷明翰心脏研究队列(1948年)中，对试验2(2,106名男性和2.639名女性)进行了长达24年的跟踪调查，研究了酒精摄入量和冠心病之间的关系。在年龄调整的原始数据和考克斯回归分析中，酒精消耗量与男性不吸烟者和重度吸烟者的冠心病死亡率都显示出强烈的U型关系，其中酒精消耗量是二次建模的。没有发现酒精对女性不吸烟者的影响。年龄调整后的数据表明，女性吸烟者的曲线呈U型，尽管这一点没有得到考克斯分析的证实。将饮酒与所有原因的死亡率联系起来的单独分析显示，除了男性死亡率的下降幅度要小得多之外，其他结果类似。在男性冠心病死亡率方面，酒精消费细分为啤酒、葡萄酒和烈性酒消费。在考克斯分析中，这些饮料也被二次建模，无论是不吸烟者还是重度吸烟者，都显示出强烈的U型曲线。在不吸烟的人中，啤酒和葡萄酒比烈性酒更能降低冠心病死亡率。
The relationship between ethanol consumption and coronary heart disease was examined in the original Framingham Heart Study cohort (1948) with a 24-year follow-up from exam 2(2,106 males and 2.639 females). Ethanol consumption shows a strong U-shaped relationship with coronary heart disease mortality for male nonsmokers and heavy smokers both in the raw age-adjusted data and in the Cox regression analyses, where ethanol consumption is modeled quadratically. No ethanol effects were found for female nonsmokers. The age-adjusted data suggest a U-shape curve for female smokers, although this was not confirmed by the Cox analysis. Separate analyses relating alcohol consumption to mortality from all causes showed similar effects except that the reduction in mortality for males was much less. For male coronary heart disease mortality, ethanol consumption was subdivided into beer, wine, and spirits consumption. These beverages were also modeled quadratically in the Cox analyses, and all showed strong U-shaped curves for both nonsmokers and heavy smokers. In nonsmokers, beer and wine show greater reductions in coronary heart disease mortality than spirits.