Probing the relative contribution of the first and second responses to sensory gating indices: A meta-analysis
Probing the relative contribution of the first and second responses to sensory gating indices: A meta-analysis
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DOI：
10.1111/j.1469-8986.2010.01168.x
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发表时间：
2011-07-01
期刊：
影响因子：
3.7
通讯作者：
Boutros, Nash N.
中科院分区：
文献类型：
--
作者：
Chang, Wen-Pin;Arfken, Cynthia L.;Boutros, Nash N.
精神分裂症患者的感觉门控缺陷已经被很好地记录下来了。然而，一个核心的概念问题，即门控缺陷是由异常的初始反应(S1)引起的，还是难以减弱对重复刺激的反应(S2)，这引发了人们对S2/S1比率作为感觉门控衡量标准的有效性和实用性的怀疑。因此，这项荟萃分析研究试图确定两个基本成分(S1和S2)和比率的影响的一致性和相对大小。加权随机效应Meta分析结果显示，S1波幅、S2波幅和P50S2/S1比值的总体效应大小分别为-0.19(小)、0.65(中到大)和0.93(大)。这些结果证实，精神分裂症患者和健康对照组的S2/S1比率和重复(S2)刺激显著不同，而S1幅度的影响范围一致但较小。这些发现更有可能反映重复冗余输入的缺陷抑制，而不是对新刺激的异常反应。
Sensory gating deficit in schizophrenia patients has been well-documented. However, a central conceptual issue, regarding whether the gating deficit results from an abnormal initial response (S1) or difficulty in attenuating the response to the repeating stimulus (S2), raise doubts about the validity and utility of the S2/S1 ratio as a measure of sensory gating. This meta-analysis study, therefore, sought to determine the consistency and relative magnitude of the effect of the two essential components (S1 and S2) and the ratio. The results of weighted random effects meta-analysis revealed that the overall effect sizes for the S1 amplitude, S2 amplitude, and P50 S2/S1 ratio were -0.19 (small), 0.65 (medium to large), and 0.93 (large), respectively. These results confirm that the S2/S1 ratio and the repeating (S2) stimulus differ robustly between schizophrenia patients and healthy controls in contrast to the consistent but smaller effect size for the S1 amplitude. These findings are more likely to reflect defective inhibition of repeating redundant input rather than an abnormal response to novel stimuli.