Cognitive Function in Kidney Transplantation
Cognitive Function in Kidney Transplantation
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DOI：
10.1007/s40472-020-00284-0
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发表时间：
2020-09-01
影响因子：
2.1
通讯作者：
Gupta, Aditi
中科院分区：
文献类型：
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作者：
Jurgensen, Andrew;Qannus, Abd Assalam;Gupta, Aditi
综述目的：认知功能障碍在肾移植受者中很常见，并影响生活质量、移植物存活率、发病率和死亡率。在这篇综述文章中，我们讨论了流行病学，诊断，病理生理学和未来的发展方向，肾移植认知功能障碍。我们描述了移植前认知、免疫抑制和移植前后因素在移植后认知障碍中的潜在作用。最近的发现大多数肾移植患者有认知障碍。认知障碍影响移植前评估和移植后结果。未能识别认知障碍患者可能会拒绝适当的护理和及时的干预。认知障碍在肾移植中很常见，并影响结果。需要研究可改变的风险因素和可能的干预措施，以减缓肾病患者的认知能力下降。
Purpose of Review Cognitive impairment is common in kidney transplant recipients and affects quality of life, graft survival, morbidity, and mortality. In this review article we discuss the epidemiology, diagnosis, pathophysiology, and future directions for cognitive impairment in kidney transplantation. We describe the potential role of pre-transplant cognition, immunosuppression, and peri-transplant factors in post-transplant cognitive impairment. Recent Findings A majority of patients with kidney transplant have cognitive impairment. Cognitive impairment affects both pre-transplant evaluation and post-transplant outcomes. Failure to identify patients with cognitive impairment can withhold appropriate care and timely intervention. Cognitive impairment is common in kidney transplant and affects outcomes. Studies addressing modifiable risk factors and possible interventions to slow cognitive decline in patients with kidney disease are needed.