Periodontal disease: links with serum lipid/ triglyceride levels? Review and new data.
Periodontal disease: links with serum lipid/ triglyceride levels? Review and new data.
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发表时间：
2003
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通讯作者：
C. Cutler;A. Iacopino
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作者：
C. Cutler;A. Iacopino
现在有证据支持血清脂质/甘油三酯在调节宿主对感染的免疫反应中的有趣作用。本文将回顾在人类和各种动物模型中进行的关于血清脂质/甘油三酯升高（即脂血症）与牙周炎（PD）之间关系的研究。我们还将在大鼠中提供新的数据，表明胆固醇血症和PD之间存在双向关系，即PD本身可能能够调节血脂水平。这篇综述将介绍其他研究的证据表明，饮食脂质的类型是重要的免疫/炎症反应的调制。总体而言，本文提出的研究表明，进一步调查使用流行病学和实验方法是必要的。
Evidence now supports an intriguing role for serum lipids/triglycerides in modulation of the host immune response to infection. This paper will review the studies that have been conducted in humans and various animal models of the association between elevated serum lipids/triglycerides (i.e. hyperlipidaemia) and periodontitis (PD). We will also present new data in rats that suggests a bi-directional relationship between hyperlipidaemia and PD, i.e. that PD itself may be able to modulate serum lipid levels. This review will introduce evidence from other studies that the type of dietary lipids is important in the modulation of the immune/inflammatory response. Overall, the studies presented herein suggest that further investigation using epidemiological and experimental approaches is warranted.