EFFECTS OF A COMBINATION THERAPY TO ELIMINATE PORPHYROMONAS-GINGIVALIS IN REFRACTORY PERIODONTITIS
EFFECTS OF A COMBINATION THERAPY TO ELIMINATE PORPHYROMONAS-GINGIVALIS IN REFRACTORY PERIODONTITIS
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DOI：
10.1902/jop.1993.64.10.998
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发表时间：
1993-10-01
影响因子：
4.3
通讯作者：
ARNOLD, RR
中科院分区：
文献类型：
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作者：
COLLINS, JG;OFFENBACHER, S;ARNOLD, RR
本报告描述了30例难治性患者的临床和微生物学特征，以及他们在治疗后6周和3年对局部和全身联合治疗的反应。难治性治疗方案（RefTx）包括为期2周的阿莫西林/克拉维酸钾治疗方案，结合专业的、血管内给药聚维酮碘和氯hexide漱口水。87%的患者对RefTx有良好的临床反应，根据最初的菌群模式和治疗后发生的变化可分为3组（a， B， C）。预处理后牙龈卟啉单胞菌患病率为36.7%。在11例P阳性患者中，有10例患者的RefTx有效地将pg降至检测水平以下
THIS REPORT DESCRIBES THE CLINICAL AND MICROBIOLOGICAL FEATURES Of 30 refractory patients and their response to a combined local and systemic therapy at 6 weeks and 3 years following treatment. The refractory treatment protocol (RefTx) consisted of a 2-week regimen of amoxicillin/clavulanate potassium in conjunction with professional, intrasulcular delivery of povidone iodine, and chlorhexide mouthwash rinses b.i.d. Eightyseven percent of the patients had favorable clinical responses to the RefTx and could be divided into 3 groups (A, B, C) based upon initial flora patterns and the shifts that occurred following treatment. Pretreatment prevalence of Porphyromonas gingivalis (P.g.) was 36.7%. The RefTx was effective in reducing P.g. below detection levels in 10 of the 11 positive patients at P