Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors.
Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors.
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DOI：
10.1038/s42003-021-02434-1
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发表时间：
2021-07-26
影响因子：
5.9
通讯作者：
Catteruccia F
中科院分区：
文献类型：
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作者：
Adams KL;Sawadogo SP;Nignan C;Niang A;Paton DG;Robert Shaw W;South A;Wang J;Itoe MA;Werling K;Dabiré RK;Diabaté A;Catteruccia F
雌性科氏按蚊是非洲重要的疟疾传播媒介，一生中只交配一次。交配发生在具有高雌雄比例的空中蜂群中，其中雄性交配成功的特征在很大程度上是未知的。在这里，我们调查表皮碳氢化合物（CHCs）是否影响自然交配群在布基纳法索的交配成功。由于杀虫剂在该地区广泛用于疟疾控制，我们还确定了CHCs是否影响杀虫剂抗性水平。我们发现，交配的男性有较高的CHC丰度比未交配的对照组，这表明CHC可能是交配成功的决定因素。此外，交配的男性有较高的杀虫剂抗性下拟除虫菊酯的挑战，我们显示了抗性强度和CHC丰度之间的联系。两者合计，我们的研究结果表明，CHC丰度可能会受到性选择，除了选择杀虫剂的压力。这对杀虫剂抗性管理具有影响，因为即使在没有杀虫剂的情况下，这些性状也可能在种群中持续存在，因为它们在交配中具有益处。在这项研究中，亚当斯等人研究了表皮碳氢化合物对自然蚊子交配群中交配成功的影响。这些碳氢化合物赋予更高的交配成功率和增加的抗性拟除虫菊酯，这表明在这个人口的交配成功的杀虫剂抗性的性选择。
Anopheles coluzzii females, important malaria vectors in Africa, mate only once in their lifetime. Mating occurs in aerial swarms with a high male-to-female ratio, where traits underlying male mating success are largely unknown. Here, we investigated whether cuticular hydrocarbons (CHCs) influence mating success in natural mating swarms in Burkina Faso. As insecticides are widely used in this area for malaria control, we also determined whether CHCs affect insecticide resistance levels. We find that mated males have higher CHC abundance than unmated controls, suggesting CHCs could be determinants of mating success. Additionally, mated males have higher insecticide resistance under pyrethroid challenge, and we show a link between resistance intensity and CHC abundance. Taken together, our results suggest that CHC abundance may be subject to sexual selection in addition to selection by insecticide pressure. This has implications for insecticide resistance management, as these traits may be sustained in the population due to their benefits in mating even in the absence of insecticides. In this study, Adams et al. investigate the effect of cuticular hydrocarbons on mating success in natural mosquito mating swarms. These hydrocarbons confer both higher mating success and increased resistance to pyrethroid, suggesting sexual selection for insecticide resistance in this population secondary to mating success.