In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stability.
In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stability.
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DOI：
10.1016/j.colsurfb.2010.09.020
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发表时间：
2011-02
期刊：
影响因子：
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通讯作者：
Kwati Leonard;B. Ahmmad;H. Okamura;Junichi Kurawaki
中科院分区：
文献类型：
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作者：
Kwati Leonard;B. Ahmmad;H. Okamura;Junichi Kurawaki
我们在此报告了一种前所未有的一步绿色合成金纳米颗粒（G-AuNps），使用天然存在的韩国红参根（Panax ginseng C.A. Meyer），无需任何特殊的还原/封端剂。通过这种人参介导的过程产生的 AuNps 不会聚集，这表明其中存在的植物化学物质可以作为纳米颗粒上优异的涂层，从而提供强大的聚集屏蔽。人参生成的 AuNps 在各种缓冲液中表现出显着的体外稳定性，包括：半胱氨酸、组氨酸、盐水、氯化钠和许多 pH 范围。此外，G-AuNps 上的植物化学涂层使其无毒，使用 WST-8 计数试剂盒对正常宫颈细胞系进行的详细细胞毒性测定表明，G-AuNps 上的植物化学涂层使其无毒。本研究开辟了使用天然产物方便合成 AuNps 的新可能性，这将在光电和生物医学应用中发挥作用。
We report herein an unprecedented one-step green synthesis of gold nanoparticles (G-AuNps), using naturally occurring Korean red ginseng root (Panax ginseng C.A. Meyer) without any special reducing/capping agents. The AuNps generated through this ginseng-mediated process did not aggregate suggesting that the phytochemicals present in them serve as excellent coatings on the nanoparticles and thus, provide robust shielding from aggregations. The ginseng-generated AuNps exhibit remarkable in vitro stability in various buffers including: cysteine, histidine, saline, sodium chloride and a host of pH ranges. Furthermore, the phytochemical coatings on the G-AuNps rendered them nontoxic as demonstrated through detailed cytotoxicity assays using WST-8 counting kit, performed on normal cervical cells lines. The present study opens up a new possibility of conveniently synthesizing AuNps using natural products which will be useful in optoelectronic and biomedical applications.