Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications, and information resources
Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications, and information resources
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DOI：
10.1093/ilar.46.3.258
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发表时间：
2005-01-01
期刊：
影响因子：
2.5
通讯作者：
Weis-Garcia, F
中科院分区：
文献类型：
--
作者：
Lipman, NS;Jackson, LR;Weis-Garcia, F
抗体是宿主蛋白质，其构成适应性免疫系统的主要效应物之一。它们的效用已经得到利用，因为它们已经并将继续广泛用作诊断和研究试剂。它们也正在成为临床医生治疗疾病的重要治疗工具。抗体用于分析、纯化和富集，并介导或调节生理反应。多克隆抗体和单克隆抗体的结构和功能的概述描述了区分两者的特征。还包括对它们作为特定研究、诊断和治疗试剂的使用的有限综述，以及可用于收集有关这些主题的额外信息的印刷和电子资源列表。
Antibodies are host proteins that comprise one of the principal effectors of the adaptive immune system. Their utility has been harnessed as they have been and continue to be used extensively as a diagnostic and research reagent. They are also becoming an important therapeutic tool in the clinician's armamentarium to treat disease. Antibodies are utilized for analysis, purification, and enrichment, and to mediate or modulate physiological responses. This overview of the structure and function of polyclonal and monoclonal antibodies describes features that distinguish one from the other. A limited review of their use as specific research, diagnostic, and therapeutic reagents and a list of printed and electronic resources that can be utilized to garner additional information on these topics are also included.