A Highly Selective 3D Spiked Ultraflexible Neural (SUN) Interface for Decoding Peripheral Nerve Sensory Information
A Highly Selective 3D Spiked Ultraflexible Neural (SUN) Interface for Decoding Peripheral Nerve Sensory Information
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DOI：
10.1002/adhm.201700987
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发表时间：
2018-03-07
影响因子：
10
通讯作者：
Lee, Chengkuo
中科院分区：
文献类型：
--
作者：
Wang, Jiahui;Thow, Xin Yuan;Lee, Chengkuo
皮肤上的人工传感器被提出作为一种捕获信息的方式，该信息可以用于皮质内微刺激或外周神经内刺激，以恢复四肢瘫痪患者的感觉反馈。然而，这些人工传感器复制天然机械感受器的密度和复杂性的能力是有限的。一种相对未开发的方法是利用现有肢体中幸存的触觉和本体感受器的信号，通过记录初级感觉神经内的传递轴突。在这里，一种新的尖峰超柔性神经（SUN）接口，植入到周围神经系统捕捉感官信息，从这些机械在急性大鼠实验。这种新颖的3D设计将用于神经束内记录的尖刺结构与超柔性基底集成在一起，从而实现了与目标神经的独特共形界面。通过电极提供的高质量记录（平均信噪比为1.4），可以根据放电率区分触觉刺激和本体感受刺激。在捏趾实验中，支持向量机分类器可以实现高空间分辨率的分类。在评估SUN接口的长期记录能力方面，仍需开展进一步的工作。
Artificial sensors on the skin are proposed as a way to capture information that can be used in intracortical microstimulation or peripheral intraneural stimulation to restore sensory feedback to persons with tetraplegia. However, the ability of these artificial sensors to replicate the density and complexity of the natural mechanoreceptors is limited. One relatively unexplored approach is to make use of the signals from surviving tactile and proprioceptive receptors in existing limbs by recording from their transmitting axons within the primary sensory nerves. Here, a novel spiked ultraflexible neural (SUN) interface that is implanted into the peripheral nervous system to capture sensory information from these mechanoreceptors in acute rat experiments is described. The novel 3D design, which integrates spiked structures for intrafascicular nerve recording with an ultraflexible substrate, enables a unique conformal interface to the target nerve. With the high-quality recording (average signal-to-noise-ratio of 1.4) provided by the electrode, tactile from proprioceptive stimuli can be differentiated in terms of the firing rate. In toe pinching experiments, high spatial resolution classification can be achieved with support vector machine classifier. Further work remains to be done to assess the chronic recording capability of the SUN interface.