Enhanced Procedural Learning of Speech Sound Categories in a Genetic Variant of FOXP2
Enhanced Procedural Learning of Speech Sound Categories in a Genetic Variant of FOXP2
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DOI：
10.1523/jneurosci.4706-14.2015
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发表时间：
2015-05-20
影响因子：
5.3
通讯作者：
Maddox, W. Todd
中科院分区：
文献类型：
--
作者：
Chandrasekaran, Bharath;Yi, Han-Gyol;Maddox, W. Todd
叉头盒蛋白P2（FOXP 2）基因的突变与人类言语和语言习得的严重缺陷有关。在啮齿类动物中，当两种学习系统竞争时，FOXP 2的人源化形式促进了从陈述性学习策略到程序性学习策略的更快转换。在这里，我们研究了FOXP 2（rs6980093）的多态性在人类（214名成年人; 111名女性）与非母语语音类别学习成功的关联。神经计算模型的结果表明，GG基因型的个体更快地转向程序学习策略，这是最佳的任务。这些发现支持FOXP 2基因在调节神经学习系统功能中的适应性作用，这些神经学习系统对人类语音类别学习有直接影响。
A mutation of the forkhead box protein P2 (FOXP2) gene is associated with severe deficits in human speech and language acquisition. In rodents, the humanized form of FOXP2 promotes faster switching from declarative to procedural learning strategies when the two learning systems compete. Here, we examined a polymorphism of FOXP2 (rs6980093) in humans (214 adults; 111 females) for associations with non-native speech category learning success. Neurocomputational modeling results showed that individuals with the GG genotype shifted faster to procedural learning strategies, which are optimal for the task. These findings support an adaptive role for the FOXP2 gene in modulating the function of neural learning systems that have a direct bearing on human speech category learning.