Time trends in oligodendroglial and astrocytic tumor incidence
Time trends in oligodendroglial and astrocytic tumor incidence
复制标题
DOI：
10.1159/000115440
复制
发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Burger, Peter C.
中科院分区：
文献类型：
--
作者：
McCarthy, Bridget J.;Propp, Jennifer M.;Burger, Peter C.
背景资料：我们假设少突胶质细胞瘤、间变性少突胶质细胞瘤和混合型胶质细胞瘤的发病率从20世纪90年代早期开始显著增加，而间变性和II级星形细胞肿瘤的发病率显著下降。研究方法：从1973 - 2004年的监测，流行病学和最终结果（SEER）的公共使用数据和1985 - 2004年从美国中央脑肿瘤登记处（CBTRUS）的六个合作登记处获得的数据。SEER*Stat用于估计选定组织学的年龄校正发病率趋势和年百分比变化（APC）。联合点回归用于确定发生率随时间的急剧变化。结果如下：使用CBTRUS数据，少突胶质细胞瘤（APC = 4.7）、混合型胶质细胞瘤（APC = 3.9）和间变性少突胶质细胞瘤（APC = 12.5）的发病率（每10万人-年）均随时间推移而增加，而未另行说明的星形细胞瘤（APC = -8.1）和星形细胞瘤（APC = -2.1）的发病率则有所下降。使用SEER数据将分析限制到以后几年（1992-2004），显示少突胶质细胞瘤的发病率趋于平稳（APC = 0.5），而联合点分析显示1998年后呈下降趋势。结论：这项研究表明，在同一时期内，少突胶质细胞肿瘤发病率的增加与星形细胞肿瘤发病率的降低相对应。最大限度地减少神经胶质瘤的错误分类对于准确评估发病率、生存率和死亡率以及确定流行病学和治疗研究的同质亚组至关重要。版权所有（c）2008 S. Karger AG，巴塞尔。
Background: We hypothesized that the incidences of oligodendrogliomas, anaplastic oligodendrogliomas, and mixed gliomas have significantly increased from the early 1990s forward, while the incidences of anaplastic and grade II astrocytic tumors have significantly decreased. Methods: Data for the years 1973 - 2004 from the Surveillance, Epidemiology and End Results (SEER) public-use data and for 1985 - 2004 from six collaborating registries of the Central Brain Tumor Registry of the US (CBTRUS) were obtained. SEER*Stat was used to estimate age-adjusted incidence trends and annual percent change (APC) for selected histologies. Joinpoint regression was used to identify sharp changes in incidences occurring over time. Results: Using CBTRUS data, the incidences ( per 100,000 person-years) of oligodendrogliomas (APC = 4.7), mixed gliomas (APC = 3.9) and anaplastic oligodendrogliomas (APC = 12.5) have all increased over time, while the incidences of astrocytoma not otherwise specified (APC = -8.1) and fibrillary astrocytoma (APC = -2.1) have decreased. Restricting the analyses to later years (1992-2004) using SEER data shows the incidence of oligodendrogliomas leveling off (APC = 0.5), while joinpoint analyses demonstrate a decreasing trend after 1998. Conclusions: This study has demonstrated that increases in oligodendroglial tumor incidence correspond to decreases in astrocytic tumor incidence over the same time period. Minimizing misclassification of glial tumors will be essential for accurately assessing incidence, survival, and mortality rates, as well as for identifying homogeneous subgroups for epidemiologic and treatment studies. Copyright (c) 2008 S. Karger AG, Basel.