Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
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DOI：
10.1038/sj.ijo.0803388
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发表时间：
2007-02-01
影响因子：
4.9
通讯作者：
Van Baak, M. A.
中科院分区：
文献类型：
--
作者：
Goossens, G. H.;Blaak, E. E.;Van Baak, M. A.
背景：脂肪组织脂解的改变可能导致肥胖和胰岛素抵抗的病理生理学。我们研究了血管紧张素II (Ang II)对人体腹部皮下脂肪组织脂肪分解的影响。方法和结果：首先，用Ang II (10(-14) - 10(-6) M)刺激从9名正常体重和7名肥胖受试者获得的脂肪细胞。正常体重 (P = 0.04) 和肥胖受试者 (P < 0.001) 的脂肪细胞经 Ang II 刺激后，培养基中甘油浓度（用作脂肪细胞脂肪分解的指标）显着降低（接近 20%）。基于这些观察结果，在存在和不存在 Ang II 1 型 (AT(1)) 受体阻断的情况下，用较低剂量的 Ang II (10(-17) - 10(-6) M) 刺激另外七名肥胖受试者的脂肪细胞。 Ang II 刺激后，脂肪分解受到剂量依赖性抑制，抑制幅度约为 20% 至 25%（P = 0.001）。 AT(1)受体阻断完全消除了Ang II诱导的作用(P=0.35)。结论：Ang II通过AT1受体直接抑制正常体重和肥胖受试者腹部皮下脂肪细胞脂肪分解。
Background: Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans.Methods and results: First, adipocytes obtained from nine normal weight and seven obese subjects were stimulated with Ang II (10(-14) - 10(-6) M). Glycerol concentration in the medium, used as an indicator of adipocyte lipolysis, was significantly reduced (similar to 20%) after Ang II stimulation in adipocytes from normal weight (P = 0.04) and obese subjects (P < 0.001). Based on these observations, adipocytes of seven additional obese subjects were stimulated with lower doses of Ang II (10(-17) - 10(-6) M) in the presence and absence of Ang II type 1 (AT(1)) receptor blockade. Lipolysis was dose dependently inhibited by similar to 20 to 25% after Ang II stimulation (P = 0.001). AT(1) receptor blockade completely abolished the Ang II-induced effects (P = 0.35).Conclusion: Ang II directly inhibits abdominal subcutaneous adipocyte lipolysis in normal weight and obese subjects via the AT1 receptor.