Development, diet and dynamism: longitudinal and cross-sectional predictors of gut microbial communities in wild baboons.
Development, diet and dynamism: longitudinal and cross-sectional predictors of gut microbial communities in wild baboons.
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DOI：
10.1111/1462-2920.12852
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发表时间：
2016-05
影响因子：
5.1
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Ren T;Grieneisen LE;Alberts SC;Archie EA;Wu M
肠道细菌群落在宿主生物学中起着至关重要的作用，但到目前为止，我们缺乏关于在宿主之间以及随着时间的推移在自然种群中形成肠道微生物群的力量的信息。了解野生灵长类动物中的这些力量提供了一个有价值的比较背景，丰富了人类肠道微生物群的科学观点。为此，我们在一个经过充分研究的野生狒狒种群中测试了肠道微生物组成的预测因子。使用13年来收集的横截面和纵向样本，我们发现狒狒具有其他杂食性灵长类动物的典型肠道微生物群，尽管双歧杆菌的丰度特别高。与之前在人类和其他灵长类动物中的工作类似，我们发现发育过渡和饮食对肠道微生物组成的强烈影响。令人惊讶的是，狒狒肠道微生物群似乎是高度动态的，以至于从同一个体收集的样品仅相隔几天，就像相隔10年收集的样品一样彼此不同。尽管狒狒肠道微生物群的动态性质，我们确定了一组核心分类群，这是常见的灵长类动物，支持微生物群与其宿主物种共同多样化的假设。我们的分析在成年狒狒中发现了两种与人类和黑猩猩不同的初步肠型。
Gut bacterial communities play essential roles in host biology, but to date we lack information on the forces that shape gut microbiota between hosts and over time in natural populations. Understanding these forces in wild primates provides a valuable comparative context that enriches scientific perspectives on human gut microbiota. To this end, we tested predictors of gut microbial composition in a well-studied population of wild baboons. Using cross-sectional and longitudinal samples collected over 13 years, we found that baboons harbor gut microbiota typical of other omnivorous primates, albeit with an especially high abundance of Bifidobacterium. Similar to previous work in humans and other primates, we found strong effects of both developmental transitions and diet on gut microbial composition. Strikingly, baboon gut microbiota appeared to be highly dynamic such that samples collected from the same individual only a few days apart were as different from each other as samples collected over 10 years apart. Despite the dynamic nature of baboon gut microbiota, we identified a set of core taxa that is common among primates, supporting the hypothesis that microbiota codiversify with their host species. Our analysis identified two tentative enterotypes in adult baboons that differ from those of humans and chimpanzees.
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DOI：
10.1093/bioinformatics/bts565
发表时间：
2012-12-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Fu L;Niu B;Zhu Z;Wu S;Li W
通讯作者：
Li W
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
4.8
作者：
Fierer, Noah;Bradford, Mark A.;Jackson, Robert B.
通讯作者：
Jackson, Robert B.
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob
DOI：
10.1073/pnas.1116053109
发表时间：
2012-01-10
影响因子：
11.1
作者：
Greenblum, Sharon;Turnbaugh, Peter J.;Borenstein, Elhanan
通讯作者：
Borenstein, Elhanan