Incidence of systemic sclerosis in Allegheny County, Pennsylvania - A twenty-year study of hospital-diagnosed cases, 1963-1982
Incidence of systemic sclerosis in Allegheny County, Pennsylvania - A twenty-year study of hospital-diagnosed cases, 1963-1982
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DOI：
10.1002/art.1780400309
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发表时间：
1997-03-01
影响因子：
--
通讯作者：
Medsger, TA
中科院分区：
文献类型：
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作者：
Steen, VD;Oddis, CV;Medsger, TA
目标。[目的]了解宾夕法尼亚州匹兹堡和阿勒格尼县居民1963~1982年间医院诊断的系统性硬化症(SSC)的发病率。以1970年阿勒格尼县人口为标准，按照国际疾病分类编码检索阿勒格尼县所有医院的病历，由一名医生按照规定的标准对每个病例进行审查和核实，计算种族和性别的年龄调整发病率，并以每百万人口每年新发病例数表示。在这项为期20年的调查中发现了444例自闭症，总的年发病率为13.9‰/百万人口，总体来说，1973年至1982年的发病率比第一次调查期间翻了一番，其中增加最多的是妇女，在年轻人口(15-24岁)中，黑人妇女的自闭症发病率最高(每百万人口21.2‰)，总体来说，女性与男性的发病率为3：1，育龄期间(15-44岁)略高(3.4%)，35岁以下男性和儿童较少发生SSC。这项研究报告的SSc的发病率随着时间的推移而增加，尽管这种趋势很可能是由于检测和医疗记录技术的改进，但与女性相比，男性的发病率稳定表明，在这一人群中，SSC的发病率可能确实有所增加，特别是在女性中。
Objective. To determine the incidence of hospital-diagnosed systemic sclerosis (SSc) among residents of Pittsburgh and Allegheny County, PA, from 1963 through 1982.Methods. Medical records from all Allegheny County hospitals were searched using International Classification of Diseases codes for patients diagnosed with SSc, Each case was reviewed and verified by a physician, according to specified criteria, Age-adjusted incidence rates were computed for race and sex, and results were expressed as new cases per million population per year, with the 1970 Allegheny County population serving as the standard.Results. Four hundred forty-four cases of SSc were identified during this 20-year survey, for a total annual incidence of 13.9 per million population, Overall, the incidence rate doubled during 1973-1982 compared with the first time interval of the study,,vith the greatest increase occurring in women, Among the younger population (ages 15-24), black women had the highest incidence of SSc (21.2 per million population), Overall, the female-to-male incidence ratio was 3:1, and was slightly higher (3.4:1) during the childbearing years (ages 15-44), Men under age 35 and children infrequently developed SSc.Conclusion. The incidence of SSc reported in this study increased with time, Although this trend was most likely due to improved detection and medical record techniques, the incidence rate stability in men compared with women suggests that there may have been a true increase in the incidence of SSc in this population, particularly in women.