Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 Labeling index is a predictor for recurrence of adrenocortical carcinomas
Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 Labeling index is a predictor for recurrence of adrenocortical carcinomas
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DOI：
10.1507/endocrj.k07-079
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发表时间：
2008-02-01
影响因子：
2
通讯作者：
Ito, Sadayoshi
中科院分区：
文献类型：
--
作者：
Morimoto, Ryo;Satoh, Fumitoshi;Ito, Sadayoshi
肾上腺皮质癌(ACC)是一种罕见的高度恶性肿瘤。本研究的目的是通过免疫组织化学方法对东北大学附属医院1976-2005年间17例原发肿瘤切除并根据Weiss标准诊断为ACC的患者进行增殖标记Ki67/MIB1的预后评估。随访期为221d~10659天(约29年)，中位数为1895日。中位年龄46岁，原发肿瘤大小平均7.1 cm，最小3.5 cm。Ki67/MIB1标记指数(Ki67/MIB1LI)为1%~26%。Kaplan-Meier分析显示Ki67/MIB1LI≥7%的患者无病生存期显著缩短(P=0.0037)。Weiss标准评分中位数为5分，有丝分裂阳性13例(76.5%)。采用Weiss评分进行生存分析，评分在6分以上的患者无病生存期(P=0.0001)和总生存期(P=0.0063)均显著缩短。本研究提示Ki67/MIB1LI和Weiss评分是预测ACC患者原发灶切除后肿瘤复发的有用指标。
Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up periods ranged from 221 days to 10659 days (about 29 years) with the median of 1895 days. The median age at diagnosis was 46 years old, and the mean size of the primary tumors was 7.1 cm with the minimal of 3.5 cm. Ki67/MIB1 labeling index (Ki67/MIB1LI) ranged from 1% to 26%. Kaplan-Meier analysis revealed that patients with Ki67/MIB1LI of 7% or more were associated with significantly shortened disease-free survival (P = 0.0037). The evaluation with Weiss criteria revealed that the median score of Weiss criteria was five, and 13 patients (76.5%) presented positive findings in the criteria of mitotic rate. The survival analysis with Weiss score showed that patients with the scores of 6 or more had both significantly shortened disease-free survival (P = 0.0001) and overall survival (P = 0.0063). The present study has suggested that Ki67/MIB1LI, as well as Weiss score, is a useful predictor for tumor recurrence after resection of the primary tumors in patients with ACC.