Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).
Social Isolation Is Associated With Rapid Kidney Function Decline and the Development of Chronic Kidney Diseases in Middle-Aged and Elderly Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).
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社会隔离与中老年人肾功能快速衰退和慢性肾脏病的发展有关：中国健康与退休追踪研究（CHARLS）的发现
DOI：
10.3389/fmed.2021.782624
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发表时间：
2021
影响因子：
3.9
通讯作者：
Ding X
中科院分区：
文献类型：
--
作者：
Zhou W;Li Y;Ning Y;Gong S;Song N;Zhu B;Wang J;Zhao S;Shi Y;Ding X
背景：关于社会隔离与肾脏结局之间关系的证据有限。为了解决这一差距，本研究估计了社会隔离与肾功能快速下降以及肾功能正常的中老年人慢性肾脏病（CKD）发展的前瞻性关系。方法：我们分析了3,031名年龄≥ 45岁、基线估计肾小球滤过率（eGFR）≥ 60 ml/min/1.73 m2的参与者的数据。所有数据均来自2011年和2015年的中国健康与退休纵向研究（CHARLS）。根据血清肌酐和胱抑素C的组合估计eGFR。主要结局是肾功能快速下降，定义为eGFR每年下降> 5 ml/min/1.73 m2，而次要结局是CKD的发展，定义为eGFR下降至< 60 ml/min/1.73 m2的水平。结果：在4年的随访中，258名（8.5%）参与者经历了肾功能的快速下降，而87名（2.9%）发展为CKD。在完全校正的模型中，高度社会隔离与肾功能快速下降（OR 1.805，95% CI 1.310-2.487）和CKD发作（OR 1.842，95% CI 1.084-3.129）的风险增加显著相关。在社会隔离的五个组成部分中，未婚，不参加社会活动和独自生活独立预测肾功能下降。结论：在中国，社会隔离与肾功能正常的中老年人中eGFR快速下降和CKD发作的风险显著相关。
Background: There is limited evidence on the relationship between social isolation and renal outcomes. To address this gap, this study estimated the prospective relationship of social isolation with rapid kidney function decline and the development of chronic kidney disease (CKD) in middle-aged and elderly Chinese with normal kidney function. Methods: We analyzed data from 3,031 participants aged ≥ 45 years with baseline estimated glomerular filtration rates (eGFR) ≥ 60 ml/min/1.73 m2. All data were obtained from the 2011 and 2015 waves of the Chinese Longitudinal Study of Health and Retirement (CHARLS). eGFR was estimated based on a combination of serum creatinine and cystatin C. The primary outcome was rapid decline in renal function, as defined by an eGFR decrease of > 5 ml/min/1.73 m2 per year, while the secondary outcome was the development of CKD, as defined by an eGFR decrease to a level < 60 ml/min/1.73 m2. Results: During the follow-up of 4 years, 258 (8.5%) participants experienced a rapid decline in renal function, while 87 (2.9%) developed CKD. In the fully adjusted model, high social isolation was significantly related to an increased risk of experiencing a rapid decline in renal function (OR 1.805, 95% CI 1.310–2.487) and CKD onset (OR 1.842, 95% CI 1.084–3.129). Among the five components of social isolation, being unmarried, not participating in social activities, and living alone independently predicted declined renal function. Conclusions: Social isolation is significantly associated with the risk of rapid eGFR decline and CKD onset in middle-aged and older adults with normal kidney function in China.
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影响因子：
8.3
作者：
Divani AA;Vazquez G;Barrett AM;Asadollahi M;Luft AR
通讯作者：
Luft AR
影响因子：
9.3
作者：
Floud S;Balkwill A;Canoy D;Wright FL;Reeves GK;Green J;Beral V;Cairns BJ;Million Women Study Collaborators
通讯作者：
Million Women Study Collaborators
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
5.7
作者：
Hakulinen, Christian;Pulkki-Raback, Laura;Elovainio, Marko
通讯作者：
Elovainio, Marko
影响因子：
6.6
作者：
Luo, Fengping;Guo, Lizhi;Yu, Bin
通讯作者：
Yu, Bin