Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer.
Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer.
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转录相关细胞周期蛋白依赖性激酶在人乳腺癌中的表达和预后价值
DOI：
10.18632/aging.202595
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发表时间：
2021-03-03
期刊：
影响因子：
--
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Li N;Zheng S;Xue Z;Xiong Z;Zou Y;Tang Y;Wei WD;Yang L
转录相关的细胞周期蛋白依赖性激酶（TA-CDK）在乳腺癌中的表达和预后意义尚未得到系统研究。使用 Oncomine、GEPIA2、人类蛋白质图谱、Kaplan-Meier Plotter、cBioPortal、Metascape 和 DAVID 6.8，我们分析了乳腺癌中 TA-CDK 的表达，推断了它们的生物学功能，并评估了它们对预后的影响。乳腺癌组织中 CDK7/10/13/19 mRNA 的表达量显着高于正常乳腺组织。乳腺癌患者的生存分析显示，CDK8 表达增加与总生存期 (OS) 较差相关，CDK7 或 CDK8 表达较高与无复发生存期 (RFS) 较差相关，但 CDK13 表达较高与良好的 RFS 和 OS 相关。此外，TA-CDK 的高遗传改变率 (56%) 与较短的 OS 相关。在功能富集分析中，TA-CDK 及其邻近基因的主要 GO 富集项目包括细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性和转移酶复合物。最重要的 KEGG 通路包括细胞周期和错配修复。这些结果表明 CDK7/8/13 是乳腺癌患者潜在的预后生物标志物，并为未来研究其作为治疗靶点的有效性的研究提供了新的见解。
The expression and prognostic significance of transcription-associated cyclin-dependent kinases (TA-CDKs) in breast cancer have not been systematically investigated. Using Oncomine, GEPIA2, the Human Protein Atlas, the Kaplan-Meier Plotter, cBioPortal, Metascape, and DAVID 6.8, we profiled the expression of TA-CDKs in breast cancer, inferred their biological functions, and assessed their effect on prognosis. The expression of CDK7/10/13/19 mRNAs in breast cancer tissues was significantly higher than in normal breast tissues. Survival analysis of breast cancer patients revealed that increased CDK8 expression was associated with inferior overall survival (OS), higher expression of CDK7 or CDK8 was associated with inferior relapse-free survival (RFS), but higher expression of CDK13 was associated with favorable RFS and OS. In addition, a high genetic alteration rate (56%) in TA-CDKs was associated with shorter OS. On functional enrichment analysis, top GO enrichment items for TA-CDKs and their neighboring genes included cyclin-dependent protein serine/threonine kinase activity and transferase complex. The top KEGG pathways included cell cycle and mismatch repair. These results suggest that CDK7/8/13 are potential prognostic biomarkers for breast cancer patients and provide novel insight for future studies examining their usefulness as therapeutic targets.
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影响因子：
64.8
作者：
Kwiatkowski, Nicholas;Zhang, Tinghu;Rahl, Peter B.;Abraham, Brian J.;Reddy, Jessica;Ficarro, Scott B.;Dastur, Anahita;Amzallag, Arnaud;Ramaswamy, Sridhar;Tesar, Bethany;Jenkins, Catherine E.;Hannett, Nancy M.;McMillin, Douglas;Sanda, Takaomi;Sim, Taebo;Kim, Nam Doo;Look, Thomas;Mitsiades, Constantine S.;Weng, Andrew P.;Brown, Jennifer R.;Benes, Cyril H.;Marto, Jarrod A.;Young, Richard A.;Gray, Nathanael S.
通讯作者：
Gray, Nathanael S.
影响因子：
50.3
作者：
Quereda, Victor;Bayle, Simon;Duckett, Derek R.
通讯作者：
Duckett, Derek R.
影响因子：
7.7
作者：
Choi, Hee-Joo;Jin, Sora;Kong, Gu
通讯作者：
Kong, Gu
影响因子：
19
作者：
Goel S;DeCristo MJ;McAllister SS;Zhao JJ
通讯作者：
Zhao JJ
影响因子：
--
作者：
McDermott MS;Chumanevich AA;Lim CU;Liang J;Chen M;Altilia S;Oliver D;Rae JM;Shtutman M;Kiaris H;Győrffy B;Roninson IB;Broude EV
通讯作者：
Broude EV