Differential Sensitivities of Mammalian Nerve Fibers to Local Anesthetic Agents
Differential Sensitivities of Mammalian Nerve Fibers to Local Anesthetic Agents
复制标题
哺乳动物神经纤维对局部麻醉剂的不同敏感性
DOI：
10.1097/00000542-198012000-00006
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发表时间：
1980
期刊：
影响因子：
8.8
通讯作者：
J. Gregus
中科院分区：
文献类型：
--
作者：
A. Gissen;B. Covino;J. Gregus
研究了哺乳动物神经纤维对各种局麻药的不同敏感性。利多卡因、丁卡因、依替卡因和布比卡因表现出一致的传导阻滞模式，其中大的快速传导A纤维在最低药物浓度下被阻滞，中间B纤维在较高药物浓度下被阻滞，最小的、传导最慢的C纤维需要最高药物浓度进行传导阻滞。普鲁卡因、氯普鲁卡因、可卡因、河豚毒素和石房蛤毒素对B和C纤维的比较显示出相似的作用。这些发现表明，局部麻醉剂在对不同大小和传导速度的神经纤维的不同影响方面与其他生物应激方式相似，即，大的快速传导纤维比小的较慢传导纤维更容易受到传导阻滞的影响。讨论了本研究结果与文献中先前报告之间的差异。
The differential sensitivities of mammalian nerve fibers to various local anesthetic agents were investigated. Lidocaine, tetracaine, etidocaine, and bupivacaine demonstrated a consistent pattern of conduction blockade in which the large fast-conducting A fibers were blocked at the lowest drug concentration, the intermediate B fibers were blocked at a higher drug concentration, and the smallest, slowest-conducting C fibers required the highest drug concentration for conduction blockade. A comparison of procaine, chloroprocaine, cocaine, tetrodotoxin and saxitoxin on B and C fibers showed similar effects. These findings indicate that local anesthetic agents are similar to other biological stress modalities in terms of their differential effects on nerve fibers of various sizes and conduction velocities, i.e., the large fast-conducting fibers are more susceptible to conduction blockade than are the smaller, slower-conducting fibers. Discrepancies between results of this study and previous reports in the literature are discussed.