Fertility and use of cigarettes, alcohol, marijuana, and cocaine.
Fertility and use of cigarettes, alcohol, marijuana, and cocaine.
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DOI：
10.1016/1047-2797(93)90080-n
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发表时间：
1993-11-01
影响因子：
5.6
通讯作者：
Cramer, D W
中科院分区：
文献类型：
--
作者：
Joesoef, M R;Beral, V;Cramer, D W
这项研究表明，吸烟与怀孕时间（在2817名有生育能力的妇女中）和原发性不孕症风险（在1818名不孕妇女及其初产对照组中）的增加有关。从不吸烟的女性到受孕的平均时间为4.3个月，过去吸烟的女性为4.6个月，目前吸烟的女性为5.1个月。在调整混杂因素（风险比为0.9(0.8 - 1.0)）后，当前吸烟者的受孕延迟仍然显著。此外，当前吸烟者原发性不孕症的风险增加（奇比为1.9(1.5至2.3)）。对于饮酒，平均受孕时间和原发性不孕症的风险不随饮酒水平而变化。与从未使用过这些药物的女性相比，经常使用大麻和曾经使用过可卡因的女性的平均受孕时间要短得多。由于大麻和可卡因在年轻人中使用的增加，需要进一步调查这些关联。
This study demonstrated that cigarette smoking was associated with an increase in both time to conception (among 2817 fertile women) and risk of primary infertility (among 1818 infertile women and their primiparous control subjects). The average time to conception was 4.3 months for women who never smoked, 4.6 months for those who smoked in the past, and 5.1 months for those who currently smoked. The delay in conception for current smokers remained significant after adjusting for confounders (risk ratio of 0.9 (0.8 to 1.0)). Additionally, current smokers were at increased risk of primary infertility (odd ratios of 1.9 (1.5 to 2.3)). For alcohol use, the average time to conception and risk of primary infertility did not vary by level of consumption. The average time to conception was significantly shorter for women who had used marijuana regularly and for women who had ever used cocaine than for women who had never used these drugs. Because of the increased use of marijuana and cocaine among young adults, further investigations of these associations are needed.