Reduced interleukin-12 and transforming growth factor-ß1 in severe childhood malaria:: Relationship of cytokine balance with disease severity
Reduced interleukin-12 and transforming growth factor-ß1 in severe childhood malaria:: Relationship of cytokine balance with disease severity
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DOI：
10.1086/315762
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发表时间：
2000-09-01
影响因子：
6.4
通讯作者：
Kremsner, PG
中科院分区：
文献类型：
--
作者：
Perkins, DJ;Weinberg, JB;Kremsner, PG
在疟疾动物模型中，白细胞介素(IL)-12和转化生长因子(TGF)- β 1调节促炎性和抗炎性细胞因子之间的平衡。由于细胞因子平衡可能是产生保护性或致病性免疫反应的重要决定因素，因此对患有不同程度疟疾严重程度的加蓬儿童进行了血浆细胞因子比率检测。重症以高密度寄生虫血症和重度贫血为特征。严重疟疾患儿IL-12和tgf - β 1显著降低，而肿瘤坏死因子(TNF)- α和IL-10显著升高。与轻度疟疾组相比，严重疟疾组的tgf - β 1/IL-12和IL-10/IL-12的比率显著升高。相比之下，在严重疟疾组中，tgf - β 1/ tnf - α和IL-10/ tnf - α的比率显著降低。这些结果表明，严重疟疾的炎症级联反应的特点是抑制tgf - β 1和IL-12的保护作用，而tnf - α的过量产生可能促进有害作用，如严重贫血。
Interleukin (IL)-12 and transforming growth factor (TGF)-beta 1 regulate the balance between pro- and anti-inflammatory cytokines in animal models of malaria. Since the cytokine balance may be an important determinant of whether a protective or a pathogenic immune response develops, plasma cytokine ratios were examined in Gabonese children with various degrees of malarial severity. Severe disease was characterized by high-density parasitemia and severe anemia. IL-12 and TGF-beta 1 were significantly lower, whereas tumor necrosis factor (TNF)-alpha and IL-10 were significantly higher in children with severe malaria. The ratios of TGF-beta 1/IL-12 and IL-10/IL-12 were significantly higher in the severe, compared with the mild, malaria group. In contrast, ratios of TGF-beta 1/TNF-alpha and IL-10/TNF-alpha were significantly lower in the severe malaria group. These results suggest that the inflammatory cascade in severe malaria is characterized by suppression of the protective effects of TGF-beta 1 and IL-12, and that overproduction of TNF-alpha may promote deleterious effects, such as severe anemia.