Viral Etiology of Medically Attended Influenza-Like Illnesses in Children Less Than 5 Years Old in Suzhou, China, 2011-2014
Viral Etiology of Medically Attended Influenza-Like Illnesses in Children Less Than 5 Years Old in Suzhou, China, 2011-2014
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DOI：
10.1002/jmv.24480
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发表时间：
2016-08-01
影响因子：
12.7
通讯作者：
Zhao, Genming
中科院分区：
文献类型：
--
作者：
Wang, Dan;Chen, Liling;Zhao, Genming
中国关于流行性感冒样疾病的非流感病原学和流行病学资料有限。收集2011年4月至2014年3月在苏州大学附属儿童医院门诊就诊的5岁以下有ILI症状的儿童的口咽拭子。采用逆转录-聚合酶链式反应(RT-PCR)或聚合酶链式反应(PCR)检测11种呼吸道病毒。在3662名登记的ILI患者中，1292名(35.3%)至少有一种病毒检测呈阳性。其次是呼吸道合胞病毒(RSV)(5.6%)、副流感病毒(PIV)(4.8%)、人博卡病毒(HBoV)(3.8%)、偏肺病毒(HMPV)(3.5%)和腺病毒(ADV)(3.0%)。108例(2.9%)患者合并感染。流感病毒主要在1-3月和6-7月流行。2013-2014年冬季RSV和流感高峰期重叠。与其他病毒阳性病例相比，流感阳性病例更容易出现发热发作，RSV阳性病例更容易出现咳嗽和喘息，最常被诊断为肺炎。中国说，这些数据使人们更好地了解苏州5岁以下儿童感染ILI的病毒病原学。流感不仅是最常见的病原体，也是11种测试病原体中唯一可预防的疫苗疾病。这些发现提示了在这一流感疫苗接种目标人群中探索流感疫苗接种价值的潜在价值。(C)2016威利期刊公司。
Limited information is available on the non-influenza etiology and epidemiology of influenza-like illness (ILI) in China. From April 2011 to March 2014, we collected oropharyngeal swabs from children less than 5 years of age with symptoms of ILI who presented to the outpatient departments of Suzhou University Affiliated Children's Hospital (SCH). We used reverse transcription polymerase chain reaction (rt-PCR) or PCR to detect 11 respiratory viruses. Among 3,662 enrolled ILI patients, 1,292 (35.3%) tested positive for at least one virus. Influenza virus (16.9%) was detected most frequently (influenza A 7.4%, influenza B 9.5%), followed by respiratory syncytial virus (RSV) (5.6%), parainfluenza virus (PIV) types 1-4 (4.8%), human bocavirus (HBoV) (3.8%), human metapneumovirus (HMPV) (3.5%), and adenovirus (ADV) (3.0%). Co-infections were identified in 108 (2.9%) patients. Influenza virus predominantly circulated in January-March and June-July. The 2013-2014 winter peaks of RSV and influenza overlapped. Compared with other virus positive cases, influenza positive cases were more likely to present with febrile seizure, and RSV positive cases were more likely to present with cough and wheezing, and were most frequently diagnosed with pneumonia. These data provide a better understanding of the viral etiology of ILI among children less than 5 years of age in Suzhou, China. Influenza is not only the most frequently identified pathogen but it is also the only vaccine preventable illness among the 11 pathogens tested. Such findings suggest the potential value of exploring value of influenza vaccination among this influenza vaccination target group. (C) 2016 Wiley Periodicals, Inc.