Local anesthetics attenuate lysophosphatidic acid-induced priming in human neutrophils.
Local anesthetics attenuate lysophosphatidic acid-induced priming in human neutrophils.
复制标题
局部麻醉剂减弱溶血磷脂酸诱导的人中性粒细胞启动。
DOI：
10.1097/00000539-200104000-00044
复制
发表时间：
2001
影响因子：
5.7
通讯作者：
Durieux,ME
中科院分区：
文献类型：
--
作者：
Fischer,LG;Bremer,M;Coleman,EJ;Conrad,B;Krumm,B;Gross,A;Hollmann,MW;Mandell,G;Durieux,ME
溶血磷脂酸（LPA）影响人类中性粒细胞的两种功能，迁移和代谢活动。它作为一种化学引诱剂和引发剂，但不是激活剂。临床相关浓度的局部麻醉药可减弱对LPA的反应。
IMPLICATIONS: Lysophosphatidic acid (LPA) influences two functions of human neutrophils, migration and metabolic activity. It acted as a chemoattractant and a priming–but not activating–agent. Responses to LPA were attenuated by local anesthetics in clinically relevant concentrations.