Virally induced modulation of murine IgG antibody subclasses.
Virally induced modulation of murine IgG antibody subclasses.
复制标题
DOI：
10.1084/jem.168.6.2373
复制
发表时间：
1988-12-01
期刊：
影响因子：
--
通讯作者：
van Snick J
中科院分区：
文献类型：
--
作者：
Coutelier JP;van der Logt JT;Heessen FW;Vink A;van Snick J
在用几种病毒感染后检查鼠IgG的同种型分布。结果表明，当高丙种球蛋白血症是由感染引起的，它被限制在IgG2a，并在较小程度上，IgG2b亚类。此外，当小鼠在用可溶性蛋白抗原免疫的同时感染某些病毒时，观察到抗蛋白抗体的同种型分布发生改变，优先产生IgG 2a。这些观察结果表明，病毒感染可以积极地影响转换的免疫球蛋白和选择性刺激生产的IgG2a亚类。
The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.