Hypothesis: A Challenge of Overexpression Zfp521 in Neural Tendency of Derived Dental Pulp Stem Cells.
Hypothesis: A Challenge of Overexpression Zfp521 in Neural Tendency of Derived Dental Pulp Stem Cells.
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DOI：
10.22074/cellj.2019.5600
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发表时间：
2019-04
期刊：
影响因子：
2
通讯作者：
Nasr-Esfahani MH
中科院分区：
文献类型：
--
作者：
Behrouznezhad F;Ejeian F;Emadi-Baygi M;Nikpour P;Nasr-Esfahani MH
神经退行性疾病现已成为一项重大挑战，特别是在老年社会。大多数用于治疗这些疾病的传统策略都没有针对性，效率也很低。干细胞研究的发展引起了人们对细胞治疗作为神经组织再生的另一种概念的关注。牙髓干细胞（DPSCs）可以很容易地通过非侵入性手术获得，并且已被证明具有与众所周知的间充质干细胞相似的特性。此外，基于其神经嵴来源，DPSCs被认为具有良好的分化为神经细胞的潜力。Zfp521是一种调节许多基因表达的转录因子，包括参与神经分化过程的基因。因此，基于细胞的神经嵴起源和神经祖细胞标记物的高表达，我们推测单纯过表达Zfp521蛋白可以促进牙干细胞向神经细胞的分化，研究人员可能会发现这些细胞适合神经退行性疾病的治疗。
Neurodegenerative diseases have now become a major challenge, especially in aged societies. Most of the traditional strategies used for treatment of these diseases are untargeted and have little efficiency. Developments in stem cell investigations have given much attention to cell therapy as an alternative concept in the regeneration of neural tissues. Dental pulp stem cells (DPSCs) can be readily obtained by noninvasive procedures and have been shown to possess properties similar to well-known mesenchymal stem cells. Furthermore, based on their neural crest origin, DPSCs are considered to have a good potential to differentiate into neural cells. Zfp521 is a transcription factor that regulates expression of many genes, including ones involved in the neural differentiation process. Therefor based on neural crest origin of the cell and high expression of neural progenitor markers, we speculate that sole overexpression of Zfp521 protein can facilitate differentiation of dental stem cells to neural cells and researchers may find these cells suitable for therapeutic treatment of neurodegenerative diseases.