Disturbance in Porphyrin Metabolism Caused by Feeding Diethyl 1, 4-dihydro-2, 4, 6-trimethylpyridine-3, 5-dicarboxylate
Disturbance in Porphyrin Metabolism Caused by Feeding Diethyl 1, 4-dihydro-2, 4, 6-trimethylpyridine-3, 5-dicarboxylate
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饲喂 1, 4-二氢-2, 4, 6-三甲基吡啶-3, 5-二甲酸二乙酯引起的卟啉代谢紊乱
DOI：
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发表时间：
1959
期刊：
影响因子：
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通讯作者：
F. J. Figge
中科院分区：
文献类型：
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作者：
H. M. Solomon;F. J. Figge
对小鼠口服可力丁衍生物（1，4-二氢-2，4，6-三甲基吡啶-3，5-二羧酸二乙酯）产生卟啉代谢紊乱，其特征在于肝原卟啉和粪卟啉显著增加。用该试剂处理7天的动物的肾脏的红色荧光与肾原卟啉的大幅增加和肾尿卟啉的较小增加相关。在豚鼠中，口服可力丁衍生物产生高水平的尿粪卟啉和微量的尿胆色素原。
Summary Oral administration of collidine derivative (Diethyl 1, 4-dihydro-2, 4, 6-tri-methylpyridine-3, 5-dicarboxylate) to mice produces a disturbance in porphyrin metabolism characterized by marked increases in hepatic proto- and coproporphyrin. Red fluorescence of kidneys of animals treated with this agent for 7 days is associated with great increase in renal protoporphyrin and smaller increase in renal uroporphyrin. In the guinea pig, oral administration of collidine derivative produced high levels of urinary copropor-phyrin and trace amounts of urinary porphobilinogen.