Optical coherence tomography: a review of clinical development from bench to bedside
Optical coherence tomography: a review of clinical development from bench to bedside
复制标题
DOI：
10.1117/1.2793736
复制
发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Boppart, Stephen A.
中科院分区：
文献类型：
--
作者：
Zysk, Adam M.;Nguyen, Freddy T.;Boppart, Stephen A.
自推出以来，光学相干断层扫描（OCT）技术已经从实验室工作台发展到临床，然后又回到临床。OCT起源于低相干干涉测量和光学时域和频域反射测量领域，最初被证明用于视网膜成像，并遵循独特的商业化道路用于临床应用。与此同时，研究界也取得了重大的技术进步，包括改进的激光源、光束传输仪器和探测方案。虽然这些技术中的许多改进了视网膜成像，但它们也允许将OCT应用于许多新的临床领域。因此，OCT已在各种医疗和外科专业中得到临床证明，包括胃肠病学、皮肤病学、心脏病学和肿瘤学等。在临床中吸取的经验教训目前正在刺激实验室的一系列新的进展，这些进展将通过增加分子灵敏度、改善图像质量和提高采集速度来再次扩大OCT的临床应用。这种实验室开发和临床应用的连续循环使得OCT技术得以快速发展，并代表了将生物医学光学转换到患者床边的独特模式。这项工作介绍了OCT发展的简史，回顾了目前的临床应用，讨论了一些临床翻译的挑战，并回顾了实验室的发展，为未来的临床应用做好了准备。(c)2007年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。
Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging and followed a unique path to commercialization for clinical use. Concurrently, significant technological advances were brought about from within the research community, including improved laser sources, beam delivery instruments, and detection schemes. While many of these technologies improved retinal imaging, they also allowed for the application of OCT to many new clinical areas. As a result, OCT has been clinically demonstrated in a diverse set of medical and surgical specialties, including gastroenterology, dermatology, cardiology, and oncology, among others. The lessons learned in the clinic are currently spurring a new set of advances in the laboratory that will again expand the clinical use of OCT by adding molecular sensitivity, improving image quality, and increasing acquisition speeds. This continuous cycle of laboratory development and clinical application has allowed the OCT technology to grow at a rapid rate and represents a unique model for the translation of biomedical optics to the patient bedside. This work presents a brief history of OCT development, reviews current clinical applications, discusses some clinical translation challenges, and reviews laboratory developments poised for future clinical application. (c) 2007 Society of Photo-Optical Instrumentation Engineers.