Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury.
Progesterone decreases cortical and sub-cortical edema in young and aged ovariectomized rats with brain injury.
复制标题
DOI：
10.3233/rnn-2009-0475
复制
发表时间：
2009
影响因子：
2.8
通讯作者：
Stein DG
中科院分区：
文献类型：
--
作者：
Kasturi BS;Stein DG
在年轻成年男性和女性以及老年男性中，急性孕酮（PROG）治疗可减少创伤性脑损伤（TBI）诱导的脑水肿。为了扩展这些发现，我们测试了以下假设：脑外伤后急性PROG治疗可以减少老年女性和年轻人的皮质水肿。2. TBI会引起皮层下结构（SCS）水肿：丘脑（TH）、下丘脑（HT）、脑干（BS）和垂体前叶（AP）。3. 脑外伤后急性、全身性PROG治疗可减少SCS水肿。将切除双侧卵巢的年轻成年大鼠（n=42）和老年大鼠（n=40）分别给予内侧额叶皮质（MFC）挫伤，分别于伤后1、6和24小时给予PROG （16 mg/kg体重）或载药，并于伤后6、24和48小时处死。他们的大脑被移除，适当的区域被隔离并测量含水量。TBI诱导皮层和延迟性皮层下水肿。急性PROG治疗可减轻水肿。在tbi后5小时，年轻人和老年组的血清PROG水平均显著升高，但后者更高。我们得出结论，脑外伤后急性PROG治疗可以证明是一种有效的干预措施，可以预防或减轻年轻和老年女性全身、损伤后皮质和皮质下水肿。
Traumatic brain injury (TBI) -induced brain edema can be reduced by acute progesterone (PROG) treatment in young adult males and females, and in aged males. To extend these findings we tested these hypotheses: 1. Acute PROG treatment post-TBI will reduce cortical edema in aged females much as in young adults. 2. TBI will induce edema in sub-cortical structures (SCS): the thalamus (TH), hypothalamus (HT), brain stem (BS) and anterior pituitary (AP). 3. Acute, systemic PROG treatment post-TBI will reduce edema in SCS. Young adult (n=42) and aged (n=40), bilaterally ovariectomized rats were given medial frontal cortical (MFC) contusion injury, treated with PROG (16 mg/kg body weight) or vehicle at 1, 6 and 24 hours post-injury and killed at 6, 24 and 48 hours post-injury. Their brains were removed and the appropriate areas isolated and measured for water content. TBI induced cortical and delayed sub-cortical edema. Acute PROG treatment decreased this edema. At 5 hours post-TBI serum PROG levels were substantially elevated in both young and aged groups, but were higher in the latter. We conclude that acute PROG treatment post-TBI could prove an effective intervention to prevent or attenuate systemic, post-injury cortical and sub-cortical edema in young and aged females.