The 2010 Garrod Lecture: The dimensions of evolution in antibiotic resistance: ex unibus plurum et ex pluribus unum
The 2010 Garrod Lecture: The dimensions of evolution in antibiotic resistance: ex unibus plurum et ex pluribus unum
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DOI：
10.1093/jac/dkr214
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发表时间：
2011-08-01
影响因子：
5.2
通讯作者：
Baquero, Fernando
中科院分区：
文献类型：
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作者：
Baquero, Fernando
抗生素耐药性不仅是生物选择的结果，正如人们经常认为的那样，而是极其复杂的进化过程的结果。这些过程作用于细菌种群，但也作用于亚细胞（如质粒）或超细胞（物种，群落）进化单位的种群。考虑到漂移和选择的影响，我们对形成进化场的维度有了第一个直观的认识。我们区分两个替代的，正交的维度，分别推动进化单位走向多样化（前一个plurum）或统一（前pluribus unum）。这些维度中的每一个维度的进化都需要进化单元中的替代进化功能配置。这些配置达到多样化或统一的进化吸引子的影响下，大概与振荡动力学。这种观点说明了抗生素耐药单位的出现和进化可能结果的复杂性，并表明绝对需要对抗生素耐药性进行多层次流行病学监测，以及应用新的进化综合方法来理解和预测人类驱动的微生物世界变化的必要性。
Antibiotic resistance is not only the result of antibiotic-driven selection, as has been frequently considered, but rather the consequence of extremely complex evolutionary processes. These processes act on bacterial populations, but also on populations of subcellular (as plasmids) or supracellular (species, communities) units of evolution. The consideration of the effects of drift and selection provides a first intuition about the dimensions shaping the evolutionary field. We distinguish two alternative, orthogonal dimensions, respectively pushing evolutionary units towards diversification (ex unibus plurum) or towards unification (ex pluribus unum). Evolution in each one of these dimensions requires alternative evolutionary functional configurations in the evolving unit. These configurations are reached under the influence of evolutionary attractors for diversification or unification, presumably with an oscillatory dynamics. This view illustrates the complexity of possible outcomes in the emergence and evolution of antibiotic-resistant units, and indicates both the absolute need for multilevel epidemiological surveillance of antibiotic resistance, and the necessity of applying new evolutionary synthesis approaches to understand and predict human-driven changes in the microbial world.