Isolation and characterization of a novel lipoprotein particle from human placental extracts.
Isolation and characterization of a novel lipoprotein particle from human placental extracts.
复制标题
从人胎盘提取物中分离和表征新型脂蛋白颗粒。
DOI：
10.1016/s0006-291x(88)81123-9
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
Subbiah,MT
中科院分区：
文献类型：
--
作者：
Park,MC;Cayatte,A;Subbiah,MT
While it is believed that placental tissue is very active in lipid metabolism, the nature of lipid containing particles secreted (if any) by this tissue is not known. Lipoprotein profile of human placental tissue was analysed by gel filtration, gel electrophoresis and electron microscopy. Our studies demonstrated the presence of lipoproteins with unusual compositions. A novel major lipoprotein (which eluted in the same position on plasma VLDL) was characterized. While this lipoprotein floated at density <1.006 gr/ml and contained apo B (same as plasma VLDL) it differed from plasma VLDL in a) size, b) contining a significant amount of apo A1, and c) carried bulk of the cholesterol (80% in free form) and phospholipids. This study suggests that placental tissue might contain unique lipoproteins perhaps serving specific metabolic needs.
