Synthesis and AIE properties of PEG-PLA-PMPC based triblock amphiphilic biodegradable polymers
Synthesis and AIE properties of PEG-PLA-PMPC based triblock amphiphilic biodegradable polymers
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基于PEG-PLA-PMPC的三嵌段两亲性生物降解聚合物的合成及AIE性能
DOI：
10.1039/c5py01849h
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发表时间：
2016
影响因子：
4.6
通讯作者：
Cui Dongmei
中科院分区：
文献类型：
--
作者：
Li Chuanyang;Liu Xinli;He Shasha;Huang Yubin;Cui Dongmei
以O，N，N，O-四齿Salan钇烷基配合物为前体，一元PEG为链转移剂，采用活性永生模式（living immortal mode）对rac-LA和MPC单体进行连续开环聚合，得到了可生物降解的三嵌段两亲性共聚物（PEG-b-PLA-b-PMPC）（PEG =聚乙二醇，MPC = 5-甲基-5-炔丙氧羰基-碳酸亚丙酯）。叠氮官能化的AIE片段四苯乙烯TPE-N3和PMPC嵌段上的炔取代基之间的随后的“点击”反应迅速提供了第一个AIE官能化的可生物降解的两亲性共聚物。这些共聚物自组装成均匀的胶束，表现出定制的PL强度和良好的AIE性能，应该是有吸引力的候选人的生物成像和化学传感器的应用。
Using a O,N,N,O-tetradentate Salan yttrium alkyl complex as the precursor and monohydric PEG as the chain transfer agent, rac-LA and MPC monomers were sequentially ring-opening polymerized via living immortal mode to give biodegradable triblock amphiphilic copolymers of (PEG-b-PLA-b-PMPC) (PEG = poly(ethylene glycol) and MPC = 5-methyl-5-propargyloxycarbonyl-propylene carbonate). The subsequent “click” reaction between the azide functionalized AIE fragment tetraphenylethylene TPE-N3 and the alkyne substituent on the PMPC block provided swiftly the first AIE functionalized biodegradable amphiphilic copolymers. These copolymers self-assembled into homogeneous micelles that exhibited a tailored PL intensity and fine AIE performance, and should be attractive candidates for bioimaging and chemosensor applications.