Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway.
Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway.
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DOI：
10.1016/b978-0-12-405881-1.00012-4
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发表时间：
2013
影响因子：
--
通讯作者：
Lehmann R
中科院分区：
文献类型：
--
作者：
Hurd TR;Leblanc MG;Jones LN;DeGennaro M;Lehmann R
Under normal physiological conditions, cells use oxidants, particularly H2O2, for signal transduction during processes such as proliferation and migration. Though recent progress has been made in determining the precise role H2O2 plays in these processes, many gaps still remain. To further understand this, we describe the use of a dominant enhancer screen to identify novel components of a redox-regulated cell migration and adhesion pathway in Drosophila melanogaster. Here, we discuss our methodology and progress as well as the benefits and limitations of applying such an approach to study redox-regulated pathways. Depending on the nature of these pathways, unbiased genetic modifier screens may prove a productive way to identify novel redox-regulated signaling components.
