Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
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DOI：
10.1212/wnl.0b013e3182684646
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发表时间：
2012-09-01
期刊：
影响因子：
9.9
通讯作者：
Giladi, Nir
中科院分区：
文献类型：
--
作者：
Thaler, Avner;Mirelman, Anat;Giladi, Nir
目的：评估携带LRRK2基因G2019S突变的帕金森病(PD)患者的健康一级亲属的认知能力。结果：G2019S携带者在计算机化执行功能指数(p=0.04)和特定执行功能任务(Stroop检验，p=0.007)上得分显著降低。结论：在帕金森病高危人群中，携带LRK2G2019S突变与执行能力低下有关。神经病学(R)2012；79：1027-1032
Objective: To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene.Methods: In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 +/- 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale.Results: G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007).Conclusion: Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD. Neurology (R) 2012;79:1027-1032