New insights of aquaporin 5 in the pathogenesis of high altitude pulmonary edema.
New insights of aquaporin 5 in the pathogenesis of high altitude pulmonary edema.
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水通道蛋白5在高原肺水肿发病机制中的新见解
DOI：
10.1186/1746-1596-8-193
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发表时间：
2013-11-25
影响因子：
2.6
通讯作者：
Bai C
中科院分区：
文献类型：
--
作者：
She J;Bi J;Tong L;Song Y;Bai C
BackgroundHigh altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich edema as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which is one kind of water channels may play a role in preservation of alveolar epithelial barrier integrity in high altitude pulmonary edema (HAPE).MethodsTherefore, we established a model in Wildtype mice and AQP5 −/− mice were assingned to normoxic rest (NR), hypoxic rest (HR) and hypoxic exercise (HE) group. Mice were produced by training to walk at treadmill for exercising and chamber pressure was reduced to simulate climbing an altitude of 5000 m for 48 hours. Studies using BAL in HAPE mice to demonstrated that edema is caused leakage of albumin proteins and red cells across the alveolarcapillary barrier in the absence of any evidence of inflammation.ResultsIn this study, the Lung wet/dry weight ratio and broncholalveolar lavage protein concentrations were slightly increased in HE AQP5 −/− mice compared to wildtype mice. And histologic evidence of hemorrhagic pulmonary edema was distinctly shown in HE group. The lung Evan’s blue permeability of HE group was showed slightly increased compare to the wildtype groups, and HR group was showed a medium situation from normal to HAPE development compared with NR and HE group.ConclusionsDeletion of AQP5 slightly increased lung edema and lung injury compared to wildtype mice during HAPE development, which suggested that the AQP5 plays an important role in HAPE formation induced by high altitude simulation.
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影响因子：
3.4
作者：
Moore, M;Ma, TH;Verkman, AS
通讯作者：
Verkman, AS
DOI：
10.1165/rcmb.2006-0238oc
发表时间：
2007-03-01
影响因子：
6.4
作者：
Su, George;Hodnett, Maki;Pittet, Jean-Francois
通讯作者：
Pittet, Jean-Francois
影响因子：
3.3
作者：
Mairbäurl, H;Schwöbel, F;Bärtsch, P
通讯作者：
Bärtsch, P
关于表面活性剂蛋白A在人肺中的重要性。
影响因子：
2.6
作者：
Goldmann T;Kähler D;Schultz H;Abdullah M;Lang DS;Stellmacher F;Vollmer E
通讯作者：
Vollmer E
影响因子：
24.3
作者：
Sadovski, J.;Kuchenbuch, T.;Grau, V.
通讯作者：
Grau, V.