Residue‐Selective C-H Sulfenylation Enabled by Acid‐Activated‐Acetamidomethyl Cysteine Sulfoxide with Application to One‐Pot Stapling and Lipidation Sequence
Residue‐Selective C-H Sulfenylation Enabled by Acid‐Activated‐Acetamidomethyl Cysteine Sulfoxide with Application to One‐Pot Stapling and Lipidation Sequence
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酸激活乙酰胺甲基半胱氨酸亚砜实现残基选择性 C-H 磺酰化并应用于一锅装订和脂质化序列
DOI：
10.1002/chem.202300799
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Otaka Akira
中科院分区：
文献类型：
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作者：
Ohkawachi Kento;Anzaki Kaito;Kobayashi Daishiro;Kyan Ryuji;Yasuda Takuma;Denda Masaya;Harada Norio;Shigenaga Akira;Inagaki Nobuya;Otaka Akira
在酸性条件下，芳香（C−H）磺化反应与s -乙酰氨基甲基半胱氨酸亚砜(Cys （Acm)(O)）具有trp或tyrr选择性。红色氯阴离子队将Cys (Acm)(O)球踢进Trp球门，而蓝色三甲基硅基队将球踢进Tyr球门。看台上的质子比分支持两队。更多信息可以在A. Otaka及其同事的研究文章（DOI: 10.1002/chem）中找到。202300799)。
The aromatic (C− H) sulfenylation reaction with S-acetamidomethyl cysteine sulfoxide (Cys (Acm)(O)) can be Trp-or Tyr-selective under acidic conditions. The red chloride anion team kicks the Cys (Acm)(O) ball into the Trp goal, whereas the blue trimethylsilyl team kicks the ball into the Tyr goal. The proton scoreline in the stands supports both teams. More information can be found in the Research Article by A. Otaka and co-workers (DOI: 10.1002/chem. 202300799).