Influence of Removing the Large Retinal Vessels-related Effect on Peripapillary Vessel Density Progression Analysis in Glaucoma
Influence of Removing the Large Retinal Vessels-related Effect on Peripapillary Vessel Density Progression Analysis in Glaucoma
复制标题
DOI：
10.1097/ijg.0000000000000990
复制
发表时间：
2018-08-01
影响因子：
2
通讯作者：
Hollo, Gabor
中科院分区：
文献类型：
--
作者：
Hollo, Gabor
目的：研究从视乳头周围光学相干断层扫描血管造影进展分析中去除大血管相关信息的有效性。对于选择性乳头周围毛细血管VD进展，重新评估了使用早期软件版本（未分离毛细血管和大血管相关效应）显示无进展的乳头周围血管密度（VD）图像系列。材料和方法：使用Angiovue/RTvue-XR OCT对9例正常眼、20例治疗中的高眼压症患者的1只眼进行前瞻性视网膜神经纤维层厚度和视乳头周围VD测量，和24名正在治疗的开角型青光眼患者，间隔6个月，持续2年（5次访视）。在当前研究中，重新分析了先前分析的图像。分别使用仪器的新软件（版本2017.1，第7期更新）对上级和下部视乳头周围半野的径向视乳头周围毛细血管层中的毛细血管VD进展进行线性回归分析。结果：在4只青光眼眼中发现了统计学显著的负毛细血管VD斜率。2眼双侧半视野进展，2眼1侧半视野进展。统计学显著进展率范围为每年-1.3%至-3.2%。在2只眼中，空间对应的半视野视网膜神经纤维层厚度进展也是显著的（-1.4 μ m/y和-1.8 μ m/y）。没有正常和高眼压的眼睛表现出显着的毛细血管VD progression.Conclusions：在这项为期2年的前瞻性研究中，没有眼睛表现出乳头周围VD的进展时，所有血管相关的信息。相比之下，软件提供的大视网膜血管相关信息的删除导致17%的青光眼眼睛中检测到显著的毛细血管VD进展。
Purpose: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression.Materials and Methods: Prospective retinal nerve fiber layer thickness and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on 1 eye of 9 normal, 20 under treatment ocular hypertensive, and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits). In the current investigation the previously analyzed images were reanalyzed. Linear regression analysis for capillary VD progression in the radial peripapillary capillaries layer of the superior and inferior peripapillary hemifields, respectively, was made using the instrument's new software (version 2017.1, Phase 7 update).Results: A statistically significant negative capillary VD slope was found in 4 glaucoma eyes. Two eyes progressed in both hemifields, and 2 eyes in 1 hemifield. The rate of statistically significant progression ranged between -1.3% and-3.2% per year. In 2 eyes the spatially corresponding hemifield retinal nerve fiber layer thickness progression was also significant (-1.4 mu m/y and -1.8 mu m/y). No normal and ocular hypertensive eyes showed significant capillary VD progression.Conclusions: In this 2-year prospective study no eye showed progression for peripapillary VD when all vessel-related information was used. In contrast, software-provided removal of the large retinal vessels-related information resulted in detection of significant capillary VD progression in 17% of the glaucoma eyes.