Stroke in HIV infection and AIDS.
Stroke in HIV infection and AIDS.
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DOI：
10.1586/erc.09.72
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发表时间：
2009-10-01
影响因子：
2
通讯作者：
Berger, Joseph R
中科院分区：
文献类型：
--
作者：
Dobbs, Michael R;Berger, Joseph R
艾滋病毒/艾滋病似乎增加缺血性和出血性中风的风险。这种增加的风险在年轻的艾滋病毒感染人群中最为明显，在这些人群中，中风的其他风险因素很少明显。风险增加的潜在机制包括机会性感染性脑膜炎和血管炎、原发性HIV血管病变、凝血改变和心源性栓塞事件，尽管原因可能是多因素的或仍然是隐蔽的。随着通过有效的、高活性的抗逆转录病毒治疗更好地控制HIV，许多这些风险的作用已经减轻，只是被老龄化人口所取代，老龄化人口具有更传统的动脉粥样硬化风险因素，这些风险因素被使用蛋白酶抑制剂引起的高脂血症放大。选择适当的治疗方法来治疗HIV感染患者的卒中，取决于在确定其潜在病因方面的诊断严谨性。
HIV/AIDS appears to increase the risk of both ischemic and hemorrhagic stroke. This increased risk is most apparent in the young HIV-infected population in which other risk factors for stroke are seldom evident. Mechanisms underlying the increased risk include opportunistic infectious meningitides and vasculitides, primary HIV vasculopathy, altered coagulation and cardioembolic events, although the cause may be multifactorial or remain cryptic. With better control of HIV via effective, highly active antiretroviral therapy, the role of many of these risks has been mitigated, only to be supplanted by an aging population with more conventional atherosclerotic risk factors magnified by the hyperlipidemia attending the use of protease inhibitors. Selecting the appropriate therapy for treating stroke in the HIV-infected patient is dependent on diagnostic rigor in identifying its underlying etiology.