Multiple Roles of Glycans in Hematological Malignancies.
Multiple Roles of Glycans in Hematological Malignancies.
复制标题
聚糖在血液恶性肿瘤中的多重作用
DOI：
10.3389/fonc.2018.00364
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发表时间：
2018
影响因子：
4.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Pang X;Li H;Guan F;Li X
这三种类型的血细胞（用于携带氧气的红细胞、用于免疫保护的白色血细胞和用于伤口凝血的血小板）来自成人骨髓中的造血干/祖细胞，并且在生理调节和与局部微环境的通信中起作用以维持全身稳态。血液恶性肿瘤是相对罕见的恶性疾病，来源于两种主要的血细胞谱系：骨髓（白血病）和淋巴（淋巴瘤）。恶性克隆失去了它们的调节机制，导致产生大量功能失调的细胞并破坏正常的造血。聚糖是四种主要类型的必需生物大分子之一，沿着于核酸、蛋白质和脂质。主要聚糖亚组是N-聚糖、O-聚糖、糖胺聚糖和鞘糖脂。由聚糖相关基因的失调引起的聚糖结构的异常表达与癌症的发生和进展有关，涉及细胞信号传导和通讯、肿瘤细胞解离和侵袭、细胞-基质相互作用、肿瘤血管生成、免疫调节和转移形成。异常聚糖表达发生在大多数血液系统恶性肿瘤，特别是急性髓细胞白血病，骨髓增生性肿瘤，多发性骨髓瘤等，在这里，我们综述了最近的研究进展异常聚糖，其相关基因，及其在血液系统恶性肿瘤中的作用。我们对糖基化异常模式的机制的进一步理解将导致开发针对血液恶性肿瘤的新的、更有效的治疗方法。
The three types of blood cells (red blood cells for carrying oxygen, white blood cells for immune protection, and platelets for wound clotting) arise from hematopoietic stem/progenitor cells in the adult bone marrow, and function in physiological regulation and communication with local microenvironments to maintain systemic homeostasis. Hematological malignancies are relatively uncommon malignant disorders derived from the two major blood cell lineages: myeloid (leukemia) and lymphoid (lymphoma). Malignant clones lose their regulatory mechanisms, resulting in production of a large number of dysfunctional cells and destruction of normal hematopoiesis. Glycans are one of the four major types of essential biological macromolecules, along with nucleic acids, proteins, and lipids. Major glycan subgroups are N-glycans, O-glycans, glycosaminoglycans, and glycosphingolipids. Aberrant expression of glycan structures, resulting from dysregulation of glycan-related genes, is associated with cancer development and progression in terms of cell signaling and communication, tumor cell dissociation and invasion, cell-matrix interactions, tumor angiogenesis, immune modulation, and metastasis formation. Aberrant glycan expression occurs in most hematological malignancies, notably acute myeloid leukemia, myeloproliferative neoplasms, and multiple myeloma, etc. Here, we review recent research advances regarding aberrant glycans, their related genes, and their roles in hematological malignancies. Our improved understanding of the mechanisms that underlie aberrant patterns of glycosylation will lead to development of novel, more effective therapeutic approaches targeted to hematological malignancies.
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影响因子：
20.3
作者：
Cheng, Chieh-Lung;Hou, Hsin-An;Tien, Hwei-Fang
通讯作者：
Tien, Hwei-Fang
影响因子：
16.8
作者：
Banerji, Suneale;Wright, Alan J.;Jackson, David G.
通讯作者：
Jackson, David G.
影响因子：
5.2
作者：
Albu RI;Constantinescu SN
通讯作者：
Constantinescu SN
影响因子：
20.3
作者：
Clark, Mary C.;Pang, Mabel;Baum, Linda G.
通讯作者：
Baum, Linda G.
影响因子：
8.4
作者：
Beyer-Sehlmeyer, G;Hiddemann, W;Bertram, J
通讯作者：
Bertram, J