Novel channels of the inner mitochondrial membrane.
Novel channels of the inner mitochondrial membrane.
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线粒体内膜的新通道。
DOI：
10.1016/j.bbabio.2008.11.015
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
I. Szabó
中科院分区：
文献类型：
--
作者：
M. Zoratti;U. De Marchi;E. Gulbins;I. Szabó
除了大量的载体、交换器和“泵”，线粒体膜内含有离子传导通道，这使其对小离子具有可控的渗透性。一些已经被证明是存在于其他细胞膜上的通道的线粒体对应物。本文综述了线粒体膜内主要通道、特性、特性和功能的研究现状。目前，人们对两种K+选择性通道mtKATP和mtBKCa给予了相当大的关注。它们在“预适应”中的激活被许多人认为是保护心肌细胞和其他细胞免受后续缺血损伤的基础。我们最近发现，在凋亡淋巴细胞的内膜中，mtKV1.3在促凋亡蛋白Bax插入线粒体膜外膜后与其相互作用。刚刚发现的mtIKCas是否具有类似的细胞作用(S)还有待观察。钙离子单一转运体已被电生理鉴定，但仍有待分子鉴定。氯选择性通道以107pS通道和∼400pS孔为代表，107pS通道是通过膜片钳观察到的第一个线粒体通道，我们最近能够完全表征从结肠肿瘤细胞系分离的线粒体内膜。我们建议用它来表示渗透率转变孔的一个组成部分。现有的数据排除了先前对孔蛋白的初步鉴定，并表明它与分子上仍未确定的“最大”氯离子通道相吻合。
Along with a large number of carriers, exchangers and “pumps”, the inner mitochondrial membrane contains ion-conducting channels which endow it with controlled permeability to small ions. Some have been shown to be the mitochondrial counterpart of channels present also in other cellular membranes. The manuscript summarizes the current state of knowledge on the major inner mitochondrial membrane channels, properties, identity and proposed functions. Considerable attention is currently being devoted to two K+-selective channels, mtKATPand mtBKCa. Their activation in “preconditioning” is considered by many to underlie the protection of myocytes and other cells against subsequent ischemic damage. We have recently shown that in apoptotic lymphocytes inner membrane mtKV1.3 interacts with the pro-apoptotic protein Bax after the latter has inserted into the outer mitochondrial membrane. Whether the just-discovered mtIKCahas similar cellular role(s) remains to be seen. The Ca2+“uniporter” has been characterized electrophysiologically, but still awaits a molecular identity. Chloride-selective channels are represented by the 107 pS channel, the first mitochondrial channel to be observed by patch-clamp, and by a ∼400 pS pore we have recently been able to fully characterize in the inner membrane of mitochondria isolated from a colon tumour cell line. This we propose to represent a component of the Permeability Transition Pore. The available data exclude the previous tentative identification with porin, and indicate that it coincides instead with the still molecularly unidentified “maxi” chloride channel.
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影响因子：
64.8
作者：
Long, Stephen B.;Tao, Xiao;MacKinnon, Roderick
通讯作者：
MacKinnon, Roderick
DOI：
10.1016/j.bbrc.2007.04.110
发表时间：
2007-06-22
影响因子：
3.1
作者：
Gu, Xiang Q.;Siemen, Detlef;Haddad, Gabriel G.
通讯作者：
Haddad, Gabriel G.
DOI：
10.1073/pnas.97.14.8151
发表时间：
2000-07-05
影响因子：
11.1
作者：
Wulff, H;Miller, MJ;Chandy, KG
通讯作者：
Chandy, KG
DOI：
10.1152/ajpheart.00431.2004
发表时间：
2004-11
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Xiaoying Wang;Chang Yin;Lei Xi;R. Kukreja
通讯作者：
Xiaoying Wang;Chang Yin;Lei Xi;R. Kukreja
DOI：
10.1152/ajpcell.2000.279.4.c1123
发表时间：
2000-10
期刊：
American journal of physiology. Cell physiology
影响因子：
--
作者：
T. Schilling;Fred N. Quandt;V. Cherny;Wei Zhou;Uwe Heinemann;T. DeCoursey;Claudia Eder
通讯作者：
T. Schilling;Fred N. Quandt;V. Cherny;Wei Zhou;Uwe Heinemann;T. DeCoursey;Claudia Eder