Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program
Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program
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DOI：
10.4143/crt.2018.464
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发表时间：
2019-10-01
影响因子：
4.6
通讯作者：
Lee, Duk Hyoung
中科院分区：
文献类型：
--
作者：
Lee, Jaeho;Um, Juntae;Lee, Duk Hyoung
目的为降低肺癌死亡率，建议对高危人群进行低剂量CT筛查。多中心肺癌筛查试点项目的协议，以评估肺癌筛查的有效性和可行性，以实施国家癌症筛查计划在Korea.Materials和MethodsMultidisciplinary专家委员会组成的韩国肺癌筛查项目（K-LUCAS）制定了一个标准化的协议。K-LUCAS是一项基于人群的单臂试验，目标人群为55-74岁的高危人群，吸烟史至少为30包年。LDCT结果采用美国放射学会推荐的Lung-RADS报告。基于网络的系统采用计算机辅助检测程序编制，以协助减少诊断错误。所有目前吸烟的参与者都可获得戒烟辅导。进行了一个小的试点测试，以检查的可行性和遵守K-LUCAS.ResultsIn试点测试，256人参加了协议。参与者的平均年龄为63.2岁，只有3名参与者（1.2%）是女性。参与者的吸烟史平均为40.5包-年，53.9%的人目前吸烟。其中，86.3%有意愿再次参加肺癌筛查。目前吸烟者的平均戒烟意愿比筛查前高12.7%。在肺RADS报告中，10例（3.9%）为3级，9例（3.5%）为4级。一名参与者被诊断为肺癌。ConclusionThe协议由本研究开发的评估是可行的，进行K-LUCAS在全国范围内的多中心。
PurposeTo reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea.Materials and MethodsMultidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS.ResultsIn pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer.ConclusionThe protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.