On- versus off-responses of raccoon glabrous skin rapidly adapting cutaneous mechanoreceptors.
On- versus off-responses of raccoon glabrous skin rapidly adapting cutaneous mechanoreceptors.
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浣熊无毛皮肤快速适应皮肤机械感受器的开启反应与关闭反应。
DOI：
10.1152/jn.1980.43.6.1558
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发表时间：
1980
影响因子：
2.5
通讯作者：
PubolsJr,BH
中科院分区：
文献类型：
--
作者：
PubolsJr,BH
1.在实验条件下，研究了50个浣熊正中神经纤维与快速适应无毛皮肤的机械感受器的开和关反应，这些神经纤维的开和关反应旨在使开和关反应发生可比的机会。使用梯形刺激，提供相等的刺激压痕和回缩速度以及相等的静态位移时间和审讯间隔。主要研究结果如下：2.在刺激水平远高于位移和速度阈值的响应，80%的单位产生了更有力的响应比关闭响应（斜坡脉冲的总数测量），在6%，相反的是真实的，而在其余的14%，关闭放电是不存在的。3.开启和关闭位移阈值大致相等（开启中值，43微米;关闭中值，42微米）。然而，开启速度阈值显著低于关闭速度阈值（开启中值，1.0微米/毫秒;关闭中值，3.8微米/毫秒）。4.放电率与斜坡速度（频率= a x速度B）相关的幂函数的指数（B）对于开启响应始终大于关闭响应，但截距常数（a）对于关闭响应始终大于开启响应。5.哺乳动物快速适应（RA）机械感受器具有“线性方向性”，通常有利于对反应的先前的研究结果得到证实。6.结果进行了讨论RA mechanoreceptors和邻近皮肤的粘弹性的作用。有人认为，如果同时考虑周围组织的力学性质，那么Loewenstein和Skalak（18）对帕西尼小体的运作模式的分析也可能适用于浣熊无毛皮肤的简单真皮（快速适应）小体，至少在定性上是如此。
1. The on- and off-responses of 50 raccoon median nerve fibers associated with rapidly adapting cutaneous mechanoreceptors in glabrous skin were examined under experimental conditions designed to allow comparable opportunities for on- and off-responses to occur. Trapezoidal stimuli were utilized, providing for equal stimulus indentation and retraction velocities and equal static displacement times and intertrial intervals. Principal findings were as follows: 2. At stimulus levels well above displacement and velocity thresholds for on-responses, 80% of units yielded a more vigorous on-response than off-response (as measured by the total number of ramp impulses); in 6%, the reverse was true; while in the remaining 14%, the off-discharge was absent. 3. On and off displacement thresholds were approximately equal (on median, 43 micron; off median, 42 micron). However, on velocity thresholds were significantly lower than off velocity thresholds (on median, 1.0 micron/ms; off median, 3.8 micron/ms). 4. Exponents (b) of power functions relating discharge rate to ramp velocity (frequency = a x velocityb) were consistently greater for on-responses than for off-responses, but intercept constants (a) were consistently greater for off-responses than for on-responses. 5. Previous findings that mammalian rapidly adapting (RA) mechanoreceptors possess a “linear directionality” generally favoring on-responses were confirmed. 6. Results are discussed in relation to the role of viscoelastic properties of RA mechanoreceptors and neighboring skin. It is suggested that, when considerations is also given to the mechanical properties of surrounding tissues, the Loewenstein and Skalak (18) analysis of the mode of operation of Pacinian corpuscles might also apply, at least qualitatively, to the simple dermal (rapidly adapting) corpuscle of raccoon glabrous skin.