Invasive Mold Infections in Chronic Granulomatous Disease: A 25-Year Retrospective Survey
Invasive Mold Infections in Chronic Granulomatous Disease: A 25-Year Retrospective Survey
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DOI：
10.1093/cid/cir731
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发表时间：
2011-12-15
影响因子：
11.8
通讯作者：
Fischer, Alain
中科院分区：
文献类型：
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作者：
Blumental, Sophie;Mouy, Richard;Fischer, Alain
背景侵袭性真菌感染（IFI）是慢性肉芽肿病（CGD）患者的一种危及生命的疾病，占该人群死亡人数的三分之一。本研究提供了一个描述性的审查侵袭性霉菌感染（mIFI）的儿童CGD在一段较长的时间。在法国原发性免疫缺陷国家数据库中登记的CGD患者队列中，我们对1984年至2009年发生的经证实的mIFI事件（欧洲癌症研究和治疗组织/侵袭性真菌感染合作组和国家过敏和传染病研究所真菌病研究组2008年标准）进行了回顾性分析。在24例患者中确定了29个经证实的mIFIs。24名儿童中有13名（54%）接受伊曲康唑预防治疗。其中烟曲霉7例，构巢曲霉10例，曲霉属2例，其他机会霉菌6例（4例仅病理检查阳性）。接受伊曲康唑治疗组首次证实mIFI的发生时间晚于未接受伊曲康唑治疗组（中位mIFI发生时间为10年vs 4年; P
Background. Invasive fungal infection (IFI) represents a life-threatening condition for patients with chronic granulomatous disease (CGD) and causes one-third of deaths in this population. This study offers a descriptive review of invasive mold infection (mIFI) in children with CGD over an extended period of time.Methods. In a cohort of patients with CGD registered in the French National database for Primary Immunodeficiency, we performed a retrospective review of proven mIFI episodes (European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group 2008 criteria) occurring from 1984 through 2009.Results. Twenty-nine proven mIFIs were identified in 24 patients. Thirteen (54%) of 24 children were receiving itraconazole prophylaxis. Seven episodes were caused by Aspergillus fumigatus, 10 by Aspergillus nidulans, 2 by Aspergillus species, and 6 by other opportunistic molds (4 patients only had positive pathological examination findings). First proven mIFI occurred later in the group that received itraconazole than in the group without (median time to mIFI, 10 vs 4 years; P