Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease
Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease
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DOI：
10.1016/s0002-9378(97)80020-8
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发表时间：
1997-01-01
影响因子：
9.8
通讯作者：
MacKenzie, WR
中科院分区：
文献类型：
--
作者：
Hillis, SD;Owens, LM;MacKenzie, WR
目的：我们研究了宫外孕和盆腔炎住院治疗的风险是否随着衣原体感染的增加而增加。研究设计：采用回顾性队列设计来评估11,000名威斯康星州妇女在1985年至1992年期间有一个或多个衣原体感染的宫外孕或盆腔炎住院治疗的风险。Logistic回归被用来评估强度之间的关联复发感染和susceptibility.Results：调整后的多变量分析，我们观察到异位妊娠的风险升高的妇女谁有两个（比值比2.1，95%置信区间1.3至3.4）和三个或更多的衣原体感染（比值比4.5，95%置信区间1.8至5.3）。这些群体患盆腔炎的风险也增加（两次感染：比值比4.0，95%置信区间1.6 ~ 9.9;三次或三次以上感染：比值比6.4，95%置信区间2.2 ~ 18.4）。在诊断任何衣原体感染时，都有一个独特的预防机会，因为随后复发的妇女的生殖风险增加，后遗症
OBJECTIVE: We examined whether the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease increase with increasing numbers of chlamydial infections.STUDY DESIGN: A retrospective cohort design was used to evaluate the risks of hospitalization for ectopic pregnancy or pelvic inflammatory among 11,000 Wisconsin women who had one or more chlamydial infections between 1985 and 1992. Logistic regression was used to evaluate the strength of association between recurrent infection and sequelae.RESULTS: After adjustment in multivariate analyses, we observed elevated risks of ectopic pregnancy among women who had had two (odds ratio 2.1, 95% confidence interval 1.3 to 3.4) and three or more chlamydial infections (odds ratio 4.5, 95% confidence interval 1.8 to 5.3). These groups were also at increased risk for pelvic inflammatory (two infections: odds ratio 4.0, 95% confidence interval 1.6 to 9.9; three or more infections: odds ratio 6.4, 95% confidence interval 2.2 to 18.4).CONCLUSIONS: A unique prevention opportunity occurs at the diagnosis of any chlamydial infection because women with subsequent recurrences are at increased risk for reproductive sequelae.