Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma.
Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma.
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DOI：
10.21037/jtd.2017.07.69
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发表时间：
2017-08
影响因子：
2.5
通讯作者：
Hui-Zi Chen;E. Bertino;K. He
中科院分区：
文献类型：
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作者：
Hui-Zi Chen;E. Bertino;K. He
尽管近年来治疗手段不断扩大，但肺癌仍然是全球癌症相关死亡的主要原因（1）。全世界约80%诊断的肺癌被分类为非小细胞肺癌（NSCLC），腺癌是最常见的组织学亚型。肿瘤通过气隙扩散（STAS）最近被认为是早期肺腺癌肿瘤侵袭的一种重要模式（2）。事实上，多个独立研究组已经确定STAS对切除的I期肺腺癌患者的复发具有显著的预后影响（3-5）。
Despite an expanding armamentarium of therapies in recent years, lung cancer remains the leading cause of cancer-related deaths globally (1). Approximately 80% of lung cancers diagnosed worldwide are classified as non-small cell lung cancer (NSCLC), with adenocarcinoma being the most common histologic subtype. Tumor spread through air spaces (STAS) has recently been recognized as an important pattern of tumor invasion in early stage lung adenocarcinoma (2). Indeed, multiple independent groups have determined STAS to have a significant prognostic impact on recurrence in patients with resected stage I lung adenocarcinoma (3-5).