PLATELET AND PLASMA-LEVELS OF GLUTAMATE AND GLUTAMINE IN MIGRAINE WITH AND WITHOUT AURA
PLATELET AND PLASMA-LEVELS OF GLUTAMATE AND GLUTAMINE IN MIGRAINE WITH AND WITHOUT AURA
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DOI：
10.1046/j.1468-2982.1995.015002132.x
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发表时间：
1995-04-01
期刊：
影响因子：
4.9
通讯作者：
WELCH, KMA
中科院分区：
文献类型：
--
作者：
CANANZI, AP;DANDREA, G;WELCH, KMA
我们评估了无头痛期间有先兆和无先兆偏头痛患者的血浆和血小板谷氨酸和谷氨酰胺水平，并将结果与正常对照的结果进行了比较。有先兆和无先兆偏头痛的血浆和血小板谷氨酰胺水平均正常。无先兆偏头痛患者血浆中谷氨酸水平较高，血小板水平正常。在有先兆的偏头痛患者中，血小板中的谷氨酸水平较高，但血浆中的谷氨酸水平较低。这表明有先兆和无先兆偏头痛的兴奋性氨基酸代谢特征不同。
We evaluated plasma and platelet glutamate and glutamine levels in migraine with and without aura during headache-free periods and compared the results with those of normal controls. The plasma and platelet levels of glut amine in migraine with and without aura were normal. Migraine without aura patients had higher glutamate levels in plasma, and normal platelet levels. In migraine with aura patients, glutamate levels were high in platelets, but not in plasma. This suggests different profiles of excitatory amino acid metabolism in migraine with and without aura.